Progress toward a group B streptococcal vaccine
- 주제(키워드) group B Streptococcus , maternal immunization , Streptococcus agalactiae , vaccine
- 주제(기타) Biotechnology & Applied Microbiology; Immunology
- 설명문(일반) [Song, Joon Young] Korea Univ, Coll Med, Dept Internal Med, Seoul, South Korea; [Lim, Jae Hyang] Ewha Womans Univ, Coll Med, Dept Microbiol, Seoul, South Korea; [Lim, Sangyong; Yong, Zhi; Seo, Ho Seong] Korea Atom Energy Res Inst, Biotechnol Div, Jeongeup, South Korea; [Lim, Sangyong; Yong, Zhi; Seo, Ho Seong] Univ Sci & Technol, Dept Radiat Biotechnol & Appl Radioisotope Sci, Daejeon, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 TAYLOR & FRANCIS INC
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000160245
- 본문언어 영어
- Published As http://dx.doi.org/10.1080/21645515.2018.1493326
초록/요약
Streptococcus agalactiae (group B Streptococcus, GBS) is a leading cause of severe invasive disease in neonate, elderly, and immunocompromised patients worldwide. Despite recent advances in the diagnosis and intrapartum antibiotic prophylaxis (IAP) of GBS infections, it remains one of the most common causes of neonatal morbidity and mortality, causing serious infections. Furthermore, recent studies reported an increasing number of GBS infections in pregnant women and elderly. Although IAP is effective, it has several limitations, including increasing antimicrobial resistance and late GBS infection after negative antenatal screening. Maternal immunization is the most promising and effective countermeasure against GBS infection in neonates. However, no vaccine is available to date, but two types of vaccines, protein subunit and capsular polysaccharide conjugate vaccines, were investigated in clinical trials. Here, we provide an overview of the GBS vaccine development status and recent advances in the development of immunoassays to evaluate the GBS vaccine clinical efficacy.
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