Epigenetic memory in gene regulation and immune response
- 주제(키워드) H3K4me3 , Rpd3L HDAC , Trained Immunity , Transcriptional memory , Transcriptional Repression Memory (TREM)
- 주제(기타) Biochemistry & Molecular Biology
- 설명문(일반) [Kim, Min Young; Lee, Ji Eun; Kim, TaeSoo] Ewha Womans Univ, Dept Life Sci, Seoul 03760, South Korea; [Kim, Min Young; Lee, Ji Eun; Kim, TaeSoo] Ewha Womans Univ, Res Ctr Cellular Homeostasis, Seoul 03760, South Korea; [Kim, Lark Kyun] Yonsei Univ, Coll Med, Gangnam Severance Hosp, Severance Biomed Sci Inst, Seoul 06230, South Korea; [Kim, Lark Kyun] Yonsei Univ, Coll Med, Gangnam Severance Hosp, BK21 PLUS Project Med Sci, Seoul 06230, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 gold, Green Submitted, Green Published
- 발행기관 KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000160295
- 본문언어 영어
- Published As http://dx.doi.org/10.5483/BMBRep.2019.52.2.257
- PubMed https://pubmed.ncbi.nlm.nih.gov/30463643
초록/요약
Cells must fine-tune their gene expression programs for optimal cellular activities in their natural growth conditions. Transcriptional memory, a unique transcriptional response, plays a pivotal role in faster reactivation of genes upon environmental changes, and is facilitated if genes were previously in an active state. Hyper-activation of gene expression by transcriptional memory is critical for cellular differentiation, development, and adaptation. TREM (Transcriptional REpression Memory), a distinct type of transcriptional memory, promoting hyper-repression of unnecessary genes, upon environmental changes has been recently reported. These two transcriptional responses may optimize specific gene expression patterns, in rapidly changing environments. Emerging evidence suggests that they are also critical for immune responses. In addition to memory B and T cells, innate immune cells are transcriptionally hyperactivated by restimulation, with the same or different pathogens known as trained immunity. In this review, we briefly summarize recent progress in chromatin-based regulation of transcriptional memory, and its potential role in immune responses.
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