Saccharoquinoline, a Cytotoxic Alkaloidal Meroterpenoid from Marine-Derived Bacterium Saccharomonospora sp.
- 주제(키워드) Saccharomonospora sp , meroterpenoid , marine natural product , cytotoxicity
- 주제(기타) Chemistry, Medicinal
- 설명문(일반) [Le, Tu Cam; Lee, Jihye; Yim, Chae-Yoon; Nam, Sang-Jip] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 03760, South Korea; [Lee, Eun Ju; Chin, Jungwook; Cho, Sung Jin; Hwang, Hayoung] DGMIF, New Drug Dev Ctr, Daegu 41061, South Korea; [Lee, Jihye] REDONE Seoul, Labs Marine New Drugs, Seoul 08594, South Korea; [Hong, Ahreum] Ewha Womans Univ, Grad Sch Ind Pharmaceut Sci, Seoul 03760, South Korea; [Yang, Inho] Korea Maritime & Ocean Univ, Dept Convergence Study Ocean Sci & Technol, Busan 49112, South Korea; [Choi, Hyukjae] Yeungnam Univ, Coll Pharm, Gyongsan 38541, Gyeongsangbukdo, South Korea; [Ko, Jaeyoung] Basic Res & Innovat Div, Amorepacif R&D Unit, Yongin 17074, South Korea; [Fenical, William] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 MDPI
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000160310
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/md17020098
- PubMed https://pubmed.ncbi.nlm.nih.gov/30717397
초록/요약
A cytotoxic alkaloidal meroterpenoid, saccharoquinoline (1), has been isolated from the fermentation broth of the marine-derived bacterium Saccharomonospora sp. CNQ-490. The planar structure of 1 was elucidated by 1D, 2D NMR, and MS spectroscopic data analyzes, while the relative configuration of 1 was defined through the interpretation of NOE spectroscopic data. Saccharoquinoline (1) is composed of a drimane-type sesquiterpene unit in combination with an apparent 6,7,8-trihydroxyquinoline-2-carboxylic acid. This combination of biosynthetic pathways was observed for the first time in natural microbial products. Saccharoquinoline (1) was found to have cytotoxicity against the HCT-116 cancer cell line by inducing G1 arrest, which leads to cell growth inhibition.
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