Metal-Free Synthesis of N-Aryl-Substituted Azacycles from Cyclic Ethers Using POCI3
- 주제(기타) Chemistry, Organic
- 설명문(일반) [Minh Thanh La; Kim, Hee-Kwon] Chonbuk Natl Univ, Med Sch & Hosp, Mol Imaging & Therapeut Med Res Ctr, Dept Nucl Med, Jeonju 54907, South Korea; [Kim, Hee-Kwon] Chonbuk Natl Univ, Chonbuk Natl Univ Hosp, Biomed Res Inst, Res Inst Clin Med, Jeonju 54907, South Korea; [Kang, Soosung] Ewha Womans Univ, Coll Pharm, Seoul 03760, South Korea; [Kang, Soosung] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 AMER CHEMICAL SOC
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000160390
- 본문언어 영어
- Published As http://dx.doi.org/10.1021/acs.joc.9b00377
- PubMed https://pubmed.ncbi.nlm.nih.gov/31039311
초록/요약
A facile method for the synthesis of N-aryl-substituted azacycles from arylamines and cyclic ethers has been developed. In this study, arylamines were treated with cyclic ethers in the presence of POCI3 and DBU to provide five- and six-membered azacycles. Using this method, various azacycloalkanes, isoindolines, and tetrahydroisoquinolines were prepared in high yields. This synthetic method offers an efficient approach to the production of azacycles from cyclic ethers.
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