The Benefit of Post-Mastectomy Radiotherapy in ypN0 Patients after Neoadjuvant Chemotherapy According to Molecular Subtypes
- 주제(키워드) Breast neoplasms , Mastectomy , Neoadjuvant treatment , Radiotherapy
- 주제(기타) Oncology
- 설명문(일반) [Cho, Won Kyung; Park, Won; Choi, Doo Ho] Sungkyunkwan Univ, Sch Med, Dept Radiat Oncol, Samsung Med Ctr, 81 Irwon Ro, Seoul 06351, South Korea; [Kim, Yong Bae] Yonsei Univ, Coll Med, Yonsei Canc Ctr, Dept Radiat Oncol, Seoul, South Korea; [Kim, Jin Ho] Seoul Natl Univ, Coll Med, Dept Radiat Oncol, Seoul, South Korea; [Kim, Su Ssan] Univ Ulsan, Asan Med Ctr, Dept Radiat Oncol, Coll Med, Seoul, South Korea; [Kim, Kyubo] Ewha Womans Univ, Dept Radiat Oncol, Sch Med, Seoul, South Korea; [Kim, Jin Hee] Keimyung Univ, Sch Med, Dongsan Med Ctr, Dept Radiat Oncol, Daegu, South Korea; [Ahn, Sung-Ja] Chonnam Natl Univ, Dept Radiat Oncol, Med Sch, Gwangju, South Korea; [Lee, Sun Young] Chonbuk Natl Univ, Dept Radiat Oncol, Med Sch, Jeonju, South Korea; [Lee, Jeongshim] Inha Univ Hosp, Dept Radiat Oncol, Incheon, South Korea; [Kim, Sang-Won] Ajou Univ, Dept Radiat Oncol, Sch Med, Suwon, South Korea; [Kim, Sang-Won] Konyang Univ, Coll Med, Dept Radiat Oncol, Daejeon, South Korea; [Kwon, Jeanny] Chungnam Natl Univ, Dept Radiat Oncol, Coll Med, Daejeon, South Korea; [Ahn, Ki Jung] Inje Univ, Busan Paik Hosp, Dept Radiat Oncol, Busan, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 gold, Green Published, Green Submitted
- 발행기관 KOREAN BREAST CANCER SOC
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000160437
- 본문언어 영어
- Published As http://dx.doi.org/10.4048/jbc.2019.22.e25
- PubMed https://pubmed.ncbi.nlm.nih.gov/31281730
초록/요약
Purpose: The benefit of post-mastectomy radiation therapy (PMRT) in patients with breast cancer who achieve ypN0 following neoadjuvant chemotherapy (NAC) has not yet been established. This study aimed to identify the role of PMRT in patients who achieve ypN0 according to molecular subtype. Methods: We identified patients initially suspected with axillary disease who achieved ypN0 following NAC. From 13 institutions of the Korean Radiation Oncology Group between 2005 and 2011, a total of 189 patients were included in the analysis. Effects of PMRT on loco-regional control (LRC), disease-free survival (DFS), and overall survival (OS) were evaluated for different molecular subtypes. Results: In all patients, the prognostic effect of PMRT on LRC, DFS, or OS was not significant. Subgroups analysis showed that the effect of PMRT on LRC was different according to molecular subtype (p for interaction = 0.019). PMRT was associated with greater LRC in the luminal subtype (p = 0.046), but not in other subtypes. Conclusion: In patients who achieve ypN0 following NAC and mastectomy, PMRT shows no additional survival benefits for any molecular subtype.
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