Clinical Significance of Lymph-Node Ratio in Determining Supraclavicular Lymph-Node Radiation Therapy in pN1 Breast Cancer Patients Who Received Breast-Conserving Treatment (KROG 14-18): A Multicenter Study
- 주제(키워드) breast cancer , radiotherapy , lymph-node ratio , disease-free survival
- 주제(기타) Oncology
- 설명문(일반) [Kim, Jaeho; Kim, Jin Hee] Keimyung Univ, Dongsan Med Ctr, Dept Radiat Oncol, Sch Med, Daegu 42601, South Korea; [Park, Won; Choi, Doo Ho] Sungkyunkwan Univ, Samsung Med Ctr, Dept Radiat Oncol, Sch Med, Seoul 06351, South Korea; [Kim, Yeon-Joo; Lee, Eun Sook] Natl Canc Ctr, Res Inst & Hosp, Ctr Breast Canc, Goyang 10408, South Korea; [Shin, Kyung Hwan; Kim, Jin Ho] Seoul Natl Univ, Dept Radiat Oncol, Coll Med, Seoul 03080, South Korea; [Kim, Kyubo] Ewha Womans Univ, Mokdong Hosp, Dept Radiat Oncol, Sch Med, Seoul 07804, South Korea; [Kim, Yong Bae] Yonsei Univ, Yonsei Canc Ctr, Dept Radiat Oncol, Coll Med, Seoul 03722, South Korea; [Ahn, Sung-Ja] Chonnam Natl Univ, Dept Radiat Oncol, Med Sch, Gwangju 61469, South Korea; [Lee, Jong Hoon] Catholic Univ Korea, St Vincents Hosp, Dept Radiat Oncol, Coll Med, Seoul 06591, South Korea; [Chun, Mison] Ajou Univ, Dept Radiat Oncol, Sch Med, Suwon 16499, South Korea; [Lee, Hyung-Sik] Dong A Univ, Dong A Univ Hosp, Dept Radiat Oncol, Sch Med, Busan 49201, South Korea; [Kim, Jung Soo] Chonbuk Natl Univ, Dept Radiat Oncol, Med Sch, Jeonju 54907, South Korea; [Cha, Jihye] Wonju Severance Christian Hosp, Dept Radiat Oncol, Wonju 26426, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, Green Submitted, gold
- 발행기관 MDPI
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000160438
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/cancers11050680
- PubMed https://pubmed.ncbi.nlm.nih.gov/31100839
초록/요약
This study evaluated the clinical significance of the lymph-node ratio (LNR) and its usefulness as an indicator of supraclavicular lymph-node radiation therapy (SCNRT) in pN1 breast cancer patients with disease-free survival (DFS) outcomes. We retrospectively analyzed the clinical data of patients with pN1 breast cancer who underwent partial mastectomy and taxane-based sequential adjuvant chemotherapy with postoperative radiation therapy in 12 hospitals (n = 1121). We compared their DFS according to LNR, with a cut-off value of 0.10. The median follow-up period was 66 months (range, 3-112). Treatment failed in 73 patients (6.5%) and there was no significant difference in DFS between the SCNRT group and non-SCNRT group. High LNR (>0.10) showed significantly worse DFS in both univariate and multivariate analyses (0.010 and 0.033, respectively). In a subgroup analysis, the effect of SCNRT on DFS differed significantly among patients with LNR > 0.10 (p = 0.013). High LNR can be used as an independent prognostic factor for pN1 breast cancer patients treated with partial mastectomy and postoperative radiotherapy. It may also be useful in deciding whether to perform SCNRT to improve DFS.
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