Histological features of intracranial thrombi in stroke patients with cancer
- 주제(기타) Clinical Neurology; Neurosciences
- 설명문(일반) [Park, Hyungjong; Kim, Jayoung; Ha, Jimin; Hwang, In Gun; Kim, Kyoungsub; Kim, Young Dae; Nam, Hyo Suk; Kwon, Il; Heo, Ji Hoe] Yonsei Univ, Coll Med, Dept Neurol, 50-1 Yonsei Ro, Seoul 03722, South Korea; [Song, Tae-Jin] Ewha Womans Univ, Sch Med, Dept Neurol, Seoul, South Korea; [Park, Hyungjong; Yoo, Joonsang; Sohn, Sung-Il] Keimyung Univ, Sch Med, Dept Neurol, Daegu, South Korea; [Ahn, Seong Hwan] Chosun Univ, Sch Med, Dept Neurol, Gwanju, South Korea; [Kim, Byung Moon; Kim, Dong Joon] Yonsei Univ, Coll Med, Dept Radiol, Seoul, South Korea; [Choi, Hyun-Jung] Yonsei Univ, Coll Med, Severance Integrat Res Inst Cerebral & Cardiovasc, Seoul, South Korea; [Lee, Hye Sun] Yonsei Univ, Coll Med, Biostat Collaborat Unit, Seoul, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 WILEY
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000160482
- 본문언어 영어
- Published As http://dx.doi.org/10.1002/ana.25495
- PubMed https://pubmed.ncbi.nlm.nih.gov/31025392
초록/요약
The histological features of thrombus in stroke patients with cancer are not well known. Using immunohistochemical staining of thrombi retrieved during mechanical thrombectomy in stroke patients, thrombus compositions were compared between 16 patients with active cancer, 16 patients with inactive cancer, and 16 patients without any history of cancer. The active cancer group showed higher platelet and lower erythrocyte fractions than the inactive cancer or the control group. Four patients with vegetation showed very high platelet and low erythrocyte fractions. Patients with cryptogenic etiology in the active cancer group showed a similar pattern to those with vegetation. These findings may aid the determination of treatment strategies in cancer-associated stroke. ANN NEUROL 2019
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