Plasma Klotho concentrations predict functional outcome at three months after acute ischemic stroke patients
- 주제(키워드) Klotho , fibroblast growth factor 23 , stroke , functional outcome
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [Lee, Jun-Beom] Hongik Hosp, Dept Neurol, Seoul, South Korea; [Woo, Ho Geol; Chang, Yoonkyung; Song, Tae-Jin] Ewha Womans Univ, Coll Med, Dept Neurol, 1071 Anyangcheon Ro, Seoul 07985, South Korea; [Jin, Yoon Mi; Jo, Inho] Ewha Womans Univ, Coll Med, Dept Mol Med, Seoul, South Korea; [Kim, Jinkwon] Yonsei Univ, Gangnam Severance Hosp, Dept Neurol, Coll Med, Seoul, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published
- 발행기관 TAYLOR & FRANCIS LTD
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000160483
- 본문언어 영어
- Published As http://dx.doi.org/10.1080/07853890.2019.1617434
- PubMed https://pubmed.ncbi.nlm.nih.gov/31070492
초록/요약
Background: The Klotho protects the cardiovascular system by protecting against cell apoptosis, inhibiting the production of reactive oxygen species, and modulating inflammation. We aimed to investigate relationship of plasma Klotho concentrations with functional outcome at 3 months after acute cerebral infarction. Methods: We prospectively enrolled 262 first-ever acute cerebral infarction patients from whom a blood sample was acquired within 24 h of admission. An enzyme-linked immunosorbent assay was used for evaluating plasma Klotho concentration. Functional outcome on admission and three months was evaluated. Results: Of the 262 patients, 152 (58.0%) were men. The mean age of these patients was 64.7 years. The mean +/- standard deviation of plasma Klotho concentrations was 312.7 +/- 153.3 pg/mL. As opposed to patients with good outcome, plasma Klotho levels were lower in the poor outcome group (207.8 +/- 96.2 vs. 342.5 +/- 153.5 pg/mL, p = .001). In multivariate analysis, increased plasma Klotho concentrations were independently associated with good functional outcome (Odds ratio: 2.42, 95% confidence interval: 1.45-4.04, p < .001). Conclusions: Increased plasma Klotho concentrations were associated with good functional outcome in patients with acute ischemic stroke. We attribute these associations to the pleiotropic effects of Klotho in stroke and vascular diseases.Key message Increased plasma Klotho concentrations were associated with good functional outcome in patients with acute ischemic stroke.
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