Recent Advances in the Metabolic Engineering of Klebsiella pneumoniae: A Potential Platform Microorganism for Biorefineries
- 주제(키워드) Klebsiella pneumoniae , biorefinery , metabolic engineering , microbial cell factory , carbon utilization , biomass
- 주제(기타) Biotechnology & Applied Microbiology
- 설명문(일반) [Rhie, Mi Na; Jo, Seo Young; Chu, Luan Luong; Baritugo, Kei-Anne; Baylon, Mary Grace; Park, Si Jae] Ewha Womans Univ, Div Chem Engn & Mat Sci, Seoul 03760, South Korea; [Kim, Hee Taek; Joo, Jeong Chan] Korea Res Inst Chem Technol, Biobased Chem Res Ctr, Adv Convergent Chem Div, Daejeon 34602, South Korea; [Lee, Jinwon; Na, Jeong-Geol; Kim, Lyul Ho] Sogang Univ, Dept Chem & Biomol Engn, Seoul 04107, South Korea; [Kim, Tae Wan] Chonnam Natl Univ, Dept Biotechnol & Bioengn, Gwangju 61186, South Korea; [Park, Chulhwan] Kwangwoon Univ, Dept Chem Engn, Seoul 01897, South Korea; [Hong, Soon Ho] Univ Ulsan, Dept Chem Engn, Ulsan 44610, South Korea
- 관리정보기술 faculty
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000160491
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s12257-018-0346-x
초록/요약
The production of industrial chemicals from renewable biomass resources is a promising solution to overcome the society's dependence on petroleum and to mitigate the pollution resulting from petroleum processing. Klebsiella pneumoniae is a nutritionally versatile bacterium with numerous native pathways for the production of well-known and industrially important platform chemicals derived from various sugars. Genomic sequence analyses have shown that the K. pneumoniae genome has a high similarity with that of Escherichia coli, the most studied organism, which is used in industrial biotechnology processes for fuel and chemical production. Hence, K. pneumoniae can be considered as a promising platform microorganism that can be metabolically engineered for the high-level production of bio-based chemicals. This review highlights the substrate metabolism and the metabolic engineering strategies developed in K. pneumoniae for the production of bio-based chemicals.
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