Unenhanced Velocity-Selective MR Angiography (VS-MRA): Initial Clinical Evaluation in Patients With Peripheral Artery Disease
- 주제(키워드) unenhanced MRA , velocity-selective magnetization preparation , peripheral artery disease
- 주제(기타) Radiology, Nuclear Medicine & Medical Imaging
- 설명문(일반) [Shin, Taehoon] Ewha Womans Univ, Div Mech & Biomed Engn, 52 Ewhayeodae Gil, Seoul 03760, South Korea; [Shin, Taehoon; Menon, Rajiv G.] Univ Maryland, Dept Diagnost Radiol & Nucl Med, Baltimore, MD 21201 USA; [Menon, Rajiv G.] NYU, Dept Radiol, 560 1St Ave, New York, NY 10016 USA; [Thomas, Rahul B.; Cavallo, Armando U.; Rajagopalan, Sanjay] Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USA; [Cavallo, Armando U.] Policlin Tor Vergata, Dept Diagnost & Mol Imaging Intervent Radiol & Ra, Rome, Italy; [Sarkar, Rajabraka; Crawford, Robert S.] Univ Maryland, Div Vasc & Endovasc Surg, Baltimore, MD 21201 USA; [Rajagopalan, Sanjay] Univ Maryland, Div Cardiovasc Med, Baltimore, MD 21201 USA
- 관리정보기술 faculty
- 등재 SCIE, SCOPUS
- OA유형 Green Accepted
- 발행기관 WILEY
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000160497
- 본문언어 영어
- Published As http://dx.doi.org/10.1002/jmri.26268
- PubMed https://pubmed.ncbi.nlm.nih.gov/30211442
초록/요약
BackgroundSafe and accurate imaging of the peripheral arterial system is important for diagnosis and treatment planning of patients with peripheral artery disease (PAD). PurposeTo evaluate image quality and diagnostic performance of unenhanced magnetic resonance angiography (MRA) based on velocity-selective (VS) magnetization preparation (termed VS-MRA). Study TypeProspective. PopulationThirty-one symptomatic PAD patients underwent VS-MRA. Twenty-four of them underwent clinical digital subtraction angiography (DSA) examination, 18.85.2 days after the MR scans. Field Strength/Sequence1.5T MRI that included VS-MRA (homemade research sequence) and phase-contrast flow imaging (clinical sequence). AssessmentImage quality (0: nondiagnostic, 3: excellent) and stenosis severity (0: normal, 3: occlusion) of VS-MRA images were assessed independently by three reviewers. Arterial signal-to-noise-ratio (SNR) and artery-to-muscle contrast-to-noise ratio (CNR) were calculated. Statistical TestsThe sensitivity and specificity of VS-MRA were calculated for the detection of significant stenosis (>50%) with DSA as the reference standard. Interobserver agreement among the three reviewers was evaluated by using Cohen -statistics. ResultsThe image quality score of VS-MRA was 2.70.5 for Reader 1, 2.80.5 for Reader 2, and 2.80.4 for Reader 3; SNR and CNR were 37.8 +/- 12.5 and 30.5 +/- 11.8, respectively. Segment-based analysis revealed that VS-MRA had sensitivities of 85.3%, 74.5%, and 78.4%, respectively, for the three reviewers, and specificities of 93.5%, 96.8%, and 95.2%. The interobserver agreement for the stenosis grading was good, as demonstrated by Cohen values of 0.76 (Reader 1 vs. Reader 2), 0.82 (Reader 1 vs. Reader 3), and 0.79 (Reader 2 vs. Reader 3). Data ConclusionUnenhanced VS-MRA allows clear depiction of the peripheral arteries and accurate stenosis grading, as evidenced by high image quality scores and strong agreement with DSA. Level of Evidence: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:744-751.
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