Association between VEGFA gene polymorphisms and bleeding complications in patients maintaining therapeutic international normalized ratio
- 주제(키워드) bleeding , mechanical heart valve , therapeutic INR , VEGFA , warfarin
- 주제(기타) Pharmacology & Pharmacy
- 등재 SCIE, SCOPUS
- 발행기관 FUTURE MEDICINE LTD
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000161257
- 본문언어 영어
- Published As http://dx.doi.org/10.2217/pgs-2019-0005
- PubMed https://pubmed.ncbi.nlm.nih.gov/31068094
초록/요약
Aim: This study was designed to identify the possible effects of VEGFA polymorphisms on the occurrence of bleeding complications in patients with mechanical heart valves who have achieved therapeutic international normalized ratio (INR). Materials & methods: 13 SNPs of VEGFA were analyzed. Uni- and multi-variate analyses were conducted to identify associations between polymorphisms and bleeding complications. Results & conclusion: Patients with the CC genotype of rs35410204 had an approximately tenfold higher bleeding complication than those with the T allele. For rs866236, patients who had wild-type homozygotes showed an approximately 2.9-fold higher bleeding complication than C allele carriers. This study demonstrated that bleeding complications during warfarin therapy are associated with VEGFA polymorphisms in patients with mechanical heart valves.
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