Total Synthesis of Hoiamide A Using an Evans-Tishchenko Reaction as a Key Step
- 등재 SCIE, SCOPUS
- 발행기관 American Chemical Society
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000161277
- 본문언어 영어
- Published As http://dx.doi.org/10.1021/acs.orglett.9b01735
- PubMed https://pubmed.ncbi.nlm.nih.gov/31274327
초록/요약
The first total synthesis of neurotoxic cyclodepsipeptide hoiamide A (1) has been accomplished. The synthesis features the use of an Evans-Tishchenko fragment coupling between a five-stereogenic-center-containing β-hydroxyketone and a chiral aldehyde derived from threonine. Copyright © 2019 American Chemical Society.
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