Mycousfurans A and B, antibacterial usnic acid congeners from the fungus Mycosphaerella sp., isolated from a marine sediment
- 주제(키워드) Antibacterial activity , Mycosphaerella sp , Mycousfurans , Mycousnine , Placodiolic acid , Usnic acid
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Submitted, Green Published
- 발행기관 MDPI AG
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000161283
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/md17070422
- PubMed https://pubmed.ncbi.nlm.nih.gov/31331101
초록/요약
Mycousfurans (1 and 2), two new usnic acid congeners, along with (−)-mycousnine (3), (−)-placodiolic acid (4), and (+)-usnic acid (5), were isolated using high-performance liquid chromatography-ultraviolet (HPLC-UV)-guided fractionation of extracts of Mycosphaerella sp. isolated from a marine sediment. The planar structures of 1 and 2 were elucidated using 1D and 2D NMR spectra. The relative configurations of the stereogenic carbons of 1 and 2 were established via analysis of their nuclear Overhauser spectroscopy (NOESY) spectra, and their absolute configurations were determined using a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1 and 2 were found to have antibacterial activity, showing moderate activity against Kocuria rhizophila and Staphylococcus aureus. © 2019 by the authors.
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