Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment?
- 주제(키워드) heat shock protein 27 , HSP27 inhibitor , anti-cancer drugs , resistance
- 주제(기타) Oncology
- 등재 SCIE, SCOPUS
- OA유형 Green Submitted, gold, Green Published
- 발행기관 MDPI
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000161450
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/cancers11081195
- PubMed https://pubmed.ncbi.nlm.nih.gov/31426426
초록/요약
Heat shock protein 27 (HSP27), induced by heat shock, environmental, and pathophysiological stressors, is a multi-functional protein that acts as a protein chaperone and an antioxidant. HSP27 plays a significant role in the inhibition of apoptosis and actin cytoskeletal remodeling. HSP27 is upregulated in many cancers and is associated with a poor prognosis, as well as treatment resistance, whereby cells are protected from therapeutic agents that normally induce apoptosis. This review highlights the most recent findings and role of HSP27 in cancer, as well as the strategies for using HSP27 inhibitors for therapeutic purposes.
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