Histologically proven non- alcoholic fatty liver disease and clinically related factors in recipients after liver transplantation
- 주제(키워드) biopsy , hepatic steatosis , histology , steatohepatitis , steatosis , transplant
- 주제(기타) Surgery
- 주제(기타) Transplantation
- 등재 SCIE, SCOPUS
- 발행기관 WILEY
- 발행년도 2014
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000161826
- 본문언어 영어
- Published As http://dx.doi.org/10.1111/ctr.12343
초록/요약
Non-alcoholic fatty liver disease (NAFLD) affects a substantial proportion of the world population, and its prevalence has been increasing. The study was aimed at evaluating the prevalence and peri-transplant risk factors for post-liver transplantation (LT) NAFLD. A retrospective review was performed for adult recipients who underwent late protocol biopsy (>1yr after LT) between August 2010 and December 2012. Hepatic steatosis was reviewed and graded by hepatopathologists, and the peri-transplant factors were analyzed for relationships to histologically proven NAFLD. Total 166 biopsies had been performed in 156 recipients. NAFLD was present in 27.1% at a mean period of 35.4months between LT and biopsy, moderate and severe steatosis (33%) consisted of 28.9%. In multivariate analysis, pre-LT alcoholic cirrhosis (odds ratio [OR] 8.031, p=0.003), obesity at biopsy (OR 3.873, p=0.001), and preexisting donor graft steatosis (OR 3.147, p=0.022) were significant risk factors for post-LT NAFLD. In conclusion, NAFLD represented a considerable portion of recipients, but this prevalence was not higher than those for general population. Three risk factors were significantly related to post-LT NAFLD, and recipients with those factors should be monitored for NAFLD. Furthermore, possible progression to non-alcoholic steatohepatitis (NASH) or fibrosis and metabolic syndrome should be considered in future studies.
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