Visible Light-Induced Aromatic Difluoroalkylation
- 주제(키워드) aromatics , difluoroalkylation , heteroaromatics , iridium , visible light
- 주제(기타) Chemistry, Applied
- 주제(기타) Chemistry, Organic
- 관리정보기술 faculty
- 등재 SCIE, SCOPUS
- 발행기관 WILEY-V C H VERLAG GMBH
- 발행년도 2014
- URI http://www.dcollection.net/handler/ewha/000000161855
- 본문언어 영어
- Published As http://dx.doi.org/10.1002/adsc.201400542
초록/요약
Difluoroalkylated aromatics are important structural motifs in pharmaceutical and agrochemical applications. Herein, we report their synthesis by a mild, efficient, and convenient method using visible light photoredox catalysis. A variety of unactivated aromatics were difluoroalkylated with ethyl 2-bromo-2,2-difluoroacetate (BrCF2CO2Et) in the presence of the triscyclometalated Ir complex fac-[Ir(ppy)(3)] under visible light irradiation at room temperature. It is shown that reaction outcomes containing the CF2CO2Et moiety can be converted to a variety of other CF2-containing aromatics, demonstrating the synthetic utility of the present method.
more