A chromenone analog as an ATP-competitive, DNA non-intercalative topoisomerase II catalytic inhibitor with preferences toward the alpha isoform
- 주제(기타) Chemistry, Multidisciplinary
- 등재 SCIE, SCOPUS
- 발행기관 ROYAL SOC CHEMISTRY
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000162195
- 본문언어 영어
- Published As http://dx.doi.org/10.1039/c9cc05524j
- PubMed https://pubmed.ncbi.nlm.nih.gov/31598611
초록/요약
5-Hydroxy-2-phenyl-7-(thiiran-2-ylmethoxy)-4H-chromen-4-one (compound 52) was found as a DNA non-intercalative topo II specific catalytic inhibitor by targeting its ATP-binding domain. Showing changes in interaction with Mg2+, it exhibited highly selective properties against the alpha -isoform with less toxicity, unlike other topo II poisons, such as etoposide.
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