Analysis of microarray right-censored data through fused sliced inverse regression
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 Nature Publishing Group
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000162357
- 본문언어 영어
- Published As http://dx.doi.org/10.1038/s41598-019-51441-0
- PubMed https://pubmed.ncbi.nlm.nih.gov/31641157
초록/요약
Sufficient dimension reduction (SDR) for a regression pursue a replacement of the original p-dimensional predictors with its lower-dimensional linear projection. The so-called sliced inverse regression (SIR; [5]) arguably has the longest history in SDR methodologies, but it is still one of the most popular one. The SIR is known to be easily affected by the number of slices, which is one of its critical deficits. Recently, a fused approach for SIR is proposed to relieve this weakness, which fuses the kernel matrices computed by the SIR application from various numbers of slices. In the paper, the fused SIR is applied to a large-p-small n regression of a high-dimensional microarray right-censored data to show its practical advantage over usual SIR application. Through model validation, it is confirmed that the fused SIR outperforms the SIR with any number of slices under consideration. © 2019, The Author(s).
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