Constituents of the leaves and twigs of Elaeagnus umbellata and their proliferative effects on human keratinocyte HaCaT cells
- 주제(키워드) Cell proliferation , Elaeagnaceae , Elaeagnus umbellata , Flavonoid glycoside , HaCaT keratinocyte , Serotonin derivative
- 등재 SCIE, SCOPUS
- 발행기관 Elsevier B.V.
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000162446
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.fitote.2019.104374
- PubMed https://pubmed.ncbi.nlm.nih.gov/31629867
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Bioassay-guided fractionation of an extract of leaves and twigs of Elaeagnus umbellata led to the isolation of a serotonin derivative, N-[2-(5-hydroxyl-1H-indol-3-yl)ethyl]-butanamide (1), along with six flavonoid glycosides, kaempferol-3-O-β-D-xylopyranosyl(1 → 2)-β-D-galactopyranoside-7-O-α-L-rhamnopyranoside (2), kaempferol-3-O-β-D-galactopyranoside-7-O-α-L-rhamnopyranoside (3), kaempferol-3-O-α-L-rhamnopyranosyl(1 → 6)-β-D-galactopyranoside-7-O-α-L-rhamnopyranoside (4), kaempferol-3-O-β-D-xylopyranosyl(1 → 2)-β-D-galactopyranoside (5), kaempferol-3-O-rutinoside (6), and kaempferol-3-O-β-D-glucopyranosyl(1 → 2)-β-D-galactopyranoside-7-O-α-L-rhamnopyranoside (7). Their structures were elucidated using 1D/2D nuclear magnetic resonance spectroscopy and mass spectrometry. Compounds 1–6 were evaluated for their proliferative effects on HaCaT keratinocytes; 1–5 promoted keratinocyte proliferation dose dependently. Compounds 3 and 4 showed potent activities. These results suggest that the leaves and twigs of E. umbellata have wound healing and skin cell regeneration potentials. © 2019 Elsevier B.V.
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