Pharmacokinetic alteration of paclitaxel by ferulic acid derivative
- 주제(키워드) Bioavailability , Elimination , Ferulic acid derivatives , P-glycoprotein , Paclitaxel , Pharmacokinetics
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 MDPI AG
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000162473
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/pharmaceutics11110593
- PubMed https://pubmed.ncbi.nlm.nih.gov/31717555
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
P-glycoprotein (P-gp) is known to be involved in multidrug resistance (MDR) and modulation of pharmacokinetic (PK) profiles of substrate drugs. Here, we studied the effects of synthesized ferulic acid (FA) derivatives on P-gp function in vitro and examined PK alteration of paclitaxel (PTX), a well-known P-gp substrate drug by the derivative. Compound 5c, the FA derivative chosen as a significant P-gp inhibitor among eight FA candidates by in vitro results, increased PTX AUCinf as much as twofold versus the control by reducing PTX elimination in rats. These results suggest that FA derivative can increase PTX bioavailability by inhibiting P-gp existing in eliminating organs. © 2019 by the authors.
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