Association between acute kidney injury and neurological outcome or death at 6 months in out-of-hospital cardiac arrest: A prospective, multicenter, observational cohort study
- 주제(키워드) Acute kidney injury , Out-of-hospital cardiac arrest , Targeted temperature management , Therapeutic hypothermia , Survival rate
- 주제(기타) Critical Care Medicine
- 설명문(일반) [Oh, Je Hyeok; Lee, Dong Hoon] Chung Ang Univ, Coll Med, Dept Emergency Med, 84 Heukseok Ro, Seoul 06974, South Korea; [Cho, In Soo] Hanil Gen Hosp, Dept Emergency Med, 308 Uicheon Ro, Seoul 01450, South Korea; [Youn, Chun Song] Catholic Univ, Seoul St Marys Hosp, Korea Coll Med, Dept Emergency Med, 222 Banpo Doero, Seoul 06591, South Korea; [Lee, Byung Kook] Chonnam Natl Univ, Med Sch, Dept Emergency Med, 160 Baekseo Ro, Gwangju 61469, South Korea; [Wee, Jung Hee] Catholic Univ, Yeouido St Marys Hosp, Korea Coll Med, Dept Emergency Med, 10 Yuksam Ro, Seoul 07345, South Korea; [Cha, Kyoung-Chul] Yonsei Univ, Wonju Coll Med, Dept Emergency Med, 20 Ilsan Ro, Wonju 26426, Gangwon Do, South Korea; [Chae, Minjung Kathy] Ajou Univ, Med Ctr, Dept Emergency Med, Worldcup Ro 164, Suwon 16499, South Korea; [Shin, Jonghwan] Seoul Natl Univ, Boramae Med Ctr, Coll Med, Dept Emergency Med, Boramae Ro 5 Gil, Seoul 07061, South Korea; [Park, Kyu Nam] Catholic Univ, Korea Seoul St Marys Hosp, Seoul, South Korea; [Chae, Minjung Kathy] Ajou Univ, Med Ctr, Suwon, South Korea; [Kim, Won Young] Asan Med Ctr, Seoul, South Korea; [Lee, Byung Kook; Min, Jin Hong] Chonbuk Natl Univ Hosp, Jeonju, South Korea; [Cho, Soo Hyung] Chosun Univ Hosp, Gwangju, South Korea; [Lee, Dong Hoon] Chung Ang Univ Hosp, Seoul, South Korea; [Jeong, Taeoh] Chungbuk Natl Univ Hosp, Cheongju, Chungcheongbuk, South Korea; [Jang, Tae Chang] Daegu Catholic Univ, Med Ctr, Gyongsan, Gyeongsangbuk D, South Korea; [Lee, Jae Hoon] Dong A Univ Hosp, Busan, South Korea; [Han, Chul] Ewha Womans Univ, Mokdong Hosp, Seoul, South Korea; [You, Je Sung] Gangnam Severance Hosp, Seoul, South Korea; [Lee, Young Hwan] Hallym Univ, Sacred Heart Hosp, Chuncheon Si, Gangwon Do, South Korea; [Kim, Changsun] Hanyang Univ, Guri Hosp, Seoul, South Korea; [Cho, Gyu Chong] Kangdong Sacred Heart Hosp, Seoul, South Korea; [Kim, Su Jin] Korea Univ, Anam Hosp, Seoul, South Korea; [Lee, Jong-Seok] Kyung Hee Univ, Med Ctr, Seoul, South Korea; [Lee, Mi Jin] Kyungpook Natl Univ Hosp, Daegu, South Korea; [Kim, Inbyung] Myongji Hosp, Goyang Si, Gyeonggi Do, South Korea; [Kim, Yong Hwan] Samsung Changwon Hosp, Gyeongsangnam Do, South Korea; [Sim, Min Seob] Samsung Med Ctr, Seoul, South Korea; [Shin, Jonghwan] Seoul Natl Univ, Seoul Metropolitan Govt, Boramae Med Ctr, Seoul, South Korea; [Lee, Ji Hwan] Severance Hosp, Seoul, South Korea; [Kim, Giwoon] Soonchunhyang Univ, Hosp Bucheon, Asan, Chungcheongnam, South Korea; [Moon, Hyung Jun] Soonchunhyang Univ, Hosp Cheonan, Asan, Chungcheongnam, South Korea; [Kim, Ji Hoon] Catholic Univ Korea, Bucheon St Marys Hosp, Seoul, South Korea; [Jeong, Won Jung] Catholic Univ Korea, St Vincents Hosp, Seoul, South Korea; [Oh, Joo Suk] Catholic Univ Korea, Uijeongbu St Marys Hosp, Seoul, South Korea; [Choi, Seung Pill] Catholic Univ Korea, Yeouido St Marys Hosp, Seoul, South Korea; [Cha, Kyoung-Chul] Wonju Severance Christian Hosp, Wonju, South Korea; [Choi, Wook-Jin] Ulsan Univ Hosp, Ulsan, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 W B SAUNDERS CO-ELSEVIER INC
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000165828
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.jcrc.2019.08.029
- PubMed https://pubmed.ncbi.nlm.nih.gov/31521016
초록/요약
Purpose: This study aimed to evaluate the association between acute kidney injury (AKI) and 6 months neurological outcome after out-of-hospital cardiac arrest (OHCA). Materials and methods: Prospective multi-center observational cohort included adult OHCA patients treated with targeted temperature management (TTM) across 20 hospitals in the South Korea between October 2015 and October 2017. The diagnosis of AKI was made using the Kidney Disease: Improving Global Outcomes criteria. The outcome was neurological outcome at 6 months evaluated using the modified Rankin scale (MRS). Results: Among 5676 patients with OHCA, 583 patients were enrolled. AKI developed in 348 (60%) patients. Significantly more non-AKI patients had good neurological outcome at 6 months (MRS 0-3) than AKI patients (134/235 [57%] vs. 69/348 [20%], P < .001). AKI was associated with poor neurological outcome at six months in multivariate logistic regression analysis (adjusted odds ratio: 0.206 [95% confidence interval: 0.099-0.426], P < .001]). Cox regression analysis with time-varying covariate of AKI showed that patients with AKI had a higher risk of death than those without AKI (hazard ratio: 2.223; 95% confidence interval: 1.630-3.030, P < .001). Conclusions: AKI is associated with poor neurological outcome (MRS 4-6) at 6 months in OHCA patients treated with TTM. (C) 2019 Elsevier Inc. All rights reserved.
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