Azulene-Derived Fluorescent Probe for Bioimaging: Detection of Reactive Oxygen and Nitrogen Species by Two-Photon Microscopy
- 주제(기타) Chemistry, Multidisciplinary
- 설명문(일반) [Murfin, Lloyd C.; Weber, Maria; Lopez-Alled, Carlos M.; McMullin, Claire L.; Pradaux-Caggiano, Fabienne; Bull, Steven D.; James, Tony D.; Lewis, Simon E.] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England; [Weber, Maria; Lopez-Alled, Carlos M.; Wenk, Jannis; Bull, Steven D.; James, Tony D.; Lewis, Simon E.] Univ Bath, Ctr Sustainable Circular Technol, Bath BA2 7AY, Avon, England; [Park, Sang Jun; Kim, Won Tae; Kim, Hwan Myung] Ajou Univ, Dept Energy Syst Res, Suwon 443749, South Korea; [Lyall, Catherine L.; Kociok-Kohn, Gabriele] Univ Bath, MC2, Bath BA2 7AY, Avon, England; [Wenk, Jannis] Univ Bath, Dept Chem Engn, Bath BA2 7AY, Avon, England; [Yoon, Juyoung] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea
- 등재 SCIE, SCOPUS
- OA유형 hybrid, Green Published
- 발행기관 AMER CHEMICAL SOC
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000165837
- 본문언어 영어
- Published As http://dx.doi.org/10.1021/jacs.9b09813
- PubMed https://pubmed.ncbi.nlm.nih.gov/31773957
초록/요약
Two-photon fluorescence microscopy has become an indispensable technique for cellular imaging. Whereas most two-photon fluorescent probes rely on well-known fluorophores, here we report a new fluorophore for bioimaging, namely azulene. A chemodosimeter, comprising a boronate ester receptor motif conjugated to an appropriately substituted azulene, is shown to be an effective two-photon fluorescent probe for reactive oxygen species, showing good cell penetration, high selectivity for peroxynitrite, no cytotoxicity, and excellent photostability.
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