Comparison of Neuropathic Pain in Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis
- 주제(키워드) neuromyelitis optica spectrum disorder , multiple sclerosis , neuropathic pain
- 주제(기타) Clinical Neurology
- 설명문(일반) [Hyun, Jae-Won; Jang, Hyunmin; Yu, JaeBin; Park, Na Young; Kim, Su-Hyun; Kim, Ho Jin] Natl Canc Ctr, Dept Neurol, 323 Ilsan Ro, Goyang 10408, South Korea; [Huh, So-Young] Kosin Univ, Dept Neurol, Coll Med, Busan, South Korea; [Kim, Woojun] Catholic Univ Korea, Coll Med, Dept Neurol, Seoul, South Korea; [Park, Min Su] Yeungnam Univ, Dept Neurol, Coll Med, Daegu, South Korea; [Oh, Jeeyoung] Konkuk Univ, Dept Neurol, Sch Med, Seoul, South Korea; [Park, Kee Duk] Ewha Womans Univ, Ewha Med Res Inst, Dept Neurol, Sch Med, Seoul, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 Green Published, gold
- 발행기관 KOREAN NEUROLOGICAL ASSOC
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000165875
- 본문언어 영어
- Published As http://dx.doi.org/10.3988/jcn.2020.16.1.124
- PubMed https://pubmed.ncbi.nlm.nih.gov/31942768
초록/요약
Background and Purpose To compare the characteristics of neuropathic pain in neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS). Methods From 2016 to 2018, 500 patients with NMOSD and MS from 6 referral hospitals in Korea underwent pain investigation. After the patients with current pain were matched for sex ratio and disease duration as confounding factors, PainDETECT questionnaires were assessed in 99 NMOSD and 58 MS patients to investigate neuropathic pain. The short form of the Brief Pain Inventory from 74 patients with neuropathic pain component was also analysed. Results According to the PainDETECT questionnaire, mechanical allodynia (p=0.014) and thermal hyperalgesia (p=0.011) were more severe in NMOSD patients than in MS patients. Strong involvements (score >3) of the pain in domains of tingling/prickling sensation (p=0.024), mechanical allodynia (p=0.027), sudden pain attacks (p=0.018), and thermal hyperalgesia (p=0.002) were significantly more frequent in NMOSD compared to MS patients. Among the patients experiencing pain with a neuropathic component, total pain-related interference (p= 0.045) scores were significantly higher in NMOSD patients than in MS patients. In daily life, pain interfered with normal work (p=0.045) and relationships with other people (p=0.039) more often in NMOSD patients than in MS patients. Although pain medication was prescribed more frequently in NMOSD patients, the percentage of patients experiencing medication-related pain relief was lower in those patients. Conclusions The severity of neuropathic pain and the pain-related interference in daily life were greater in NMOSD patients than in MS patients. Individualized analgesic management should be considered based on a comprehensive understanding of neuropathic pain in these patients.
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