Deubiquitinating Enzymes: A Critical Regulator of Mitosis
- 주제(키워드) mitosis , ubiquitination , deubiquitination , cancer
- 주제(기타) Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
- 설명문(일반) [Park, Jinyoung] Korea Inst Sci & Technol, Mol Recognit Res Ctr, Seoul 02792, South Korea; [Cho, Jinhong; Kim, Eunice EunKyeong] Korea Inst Sci & Technol, Biomed Res Inst, Seoul 02792, South Korea; [Song, Eun Joo] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea; [Song, Eun Joo] Ewha Womans Univ, Coll Pharm, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 MDPI
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000165898
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/ijms20235997
- PubMed https://pubmed.ncbi.nlm.nih.gov/31795161
초록/요약
Mitosis is a complex and dynamic process that is tightly regulated by a large number of mitotic proteins. Dysregulation of these proteins can generate daughter cells that exhibit genomic instability and aneuploidy, and such cells can transform into tumorigenic cells. Thus, it is important for faithful mitotic progression to regulate mitotic proteins at specific locations in the cells at a given time in each phase of mitosis. Ubiquitin-dependent modifications play critical roles in this process by regulating the degradation, translocation, or signal transduction of mitotic proteins. Here, we review how ubiquitination and deubiquitination regulate the progression of mitosis. In addition, we summarize the substrates and roles of some deubiquitinating enzymes (DUBs) crucial for mitosis and describe how they contribute error correction during mitosis and control the transition between the mitotic phases.
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