Effects of lactobacillus plantarum Q180 on postprandial lipid levels and intestinal environment: A double-blind, randomized, placebo-controlled, parallel trial
- 주제(키워드) Correlation , Intestinal microbiota , Intestinal microbiota metabolites , Lipid mechanism , LPQ180 , Postprandial lipids , Probiotics
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 MDPI AG
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000165926
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/nu12010255
- PubMed https://pubmed.ncbi.nlm.nih.gov/31963808
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Probiotics can improve the intestinal environment by enhancing beneficial bacteria to potentially regulate lipid levels; however, the underlying mechanisms remain unclear. The aim of this study was to investigate the effect of Lactobacillus plantarum Q180 (LPQ180) on postprandial lipid metabolism and the intestinal microbiome environment from a clinical perspective. A double-blind, randomized, placebo-controlled study was conducted including 70 participants of both sexes, 20 years of age and older, with healthy blood triacylglyceride (TG) levels below 200 mg/dL. Treatment with LPQ180 for 12 weeks significantly decreased LDL-cholesterol (p = 0.042) and apolipoprotein (Apo)B-100 (p = 0.003) levels, and decreased postprandial maximum concentrations (Cmax) and areas under the curve (AUC) of TG, chylomicron TG, ApoB-48, and ApoB-100. LPQ180 treatment significantly decreased total indole and phenol levels (p = 0.019). In addition, there was a negative correlation between baseline microbiota abundance and lipid marker change, which was negatively correlated with metabolites. This study suggests that LPQ180 might be developed as a functional ingredient to help maintain healthy postprandial lipid levels through modulating gut environment. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. T.
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