Expression of EEF1A1 Is Associated with Prognosis of Patients with Colon Adenocarcinoma
- 주제(키워드) cancer biomarker , colon adenocarcinoma , elongation factor-1 alpha 1 , prognosis , translation factor
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [Joung, Eun Kyo] Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul 06591, South Korea; [Kim, Jiyoung; Yoon, Nara; Maeng, Lee-so] Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Dept Pathol, Seoul 06591, South Korea; [Kim, Ji Hoon] Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Dept Gen Surg, Seoul 06591, South Korea; [Park, Sungsoo] Deargen Inc, Daejeon 34051, South Korea; [Kang, Keunsoo] Dankook Univ, Coll Nat Sci, Dept Microbiol, Cheonan 31116, South Korea; [Kim, Jeong Seon; Ahn, Young-Ho] Ewha Womans Univ, Coll Med, Dept Mol Med, Seoul 03760, South Korea; [Kim, Jeong Seon; Ahn, Young-Ho] Ewha Womans Univ, Tissue Injury Def Res Ctr, Coll Med, Seoul 03760, South Korea; [Ko, Yoon Ho; Hong, Ji Hyung] Catholic Univ Korea, Eunpyeong St Marys Hosp, Dept Internal Med, Div Oncol, Seoul 03312, South Korea; [Ko, Yoon Ho] Catholic Univ Korea, Coll Med, Canc Res Inst, Seoul 06591, South Korea; [Byun, Jae Ho] Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Dept Internal Med, Seoul 06591, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 MDPI
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000165946
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/jcm8111903
- PubMed https://pubmed.ncbi.nlm.nih.gov/31703307
초록/요약
Background: The prognostic role of the translational factor, elongation factor-1 alpha 1 (EEF1A1), in colon cancer is unclear. Objectives: The present study aimed to investigate the expression of EEF1A in tissues obtained from patients with stage II and III colon cancer and analyze its association with patient prognosis. Methods: A total of 281 patients with colon cancer who underwent curative resection were analyzed according to EEF1A1 expression. Results: The five-year overall survival in the high-EEF1A1 group was 87.7%, whereas it was 65.6% in the low-EEF1A1 expression group (hazard ratio (HR) 2.47, 95% confidence interval (CI) 1.38-4.44, p = 0.002). The five-year disease-free survival of patients with high EEF1A1 expression was 82.5%, which was longer than the rate of 55.4% observed for patients with low EEF1A1 expression (HR 2.94, 95% CI 1.72-5.04, p < 0.001). Univariate Cox regression analysis indicated that age, preoperative carcinoembryonic antigen level, adjuvant treatment, total number of metastatic lymph nodes, and EEF1A1 expression level were significant prognostic factors for death. In multivariate analysis, expression of EEF1A1 was an independent prognostic factor associated with death (HR 3.01, 95% CI 1.636-5.543, p < 0.001). EEF1A1 expression was also an independent prognostic factor for disease-free survival in multivariate analysis (HR 2.54, 95% CI 1.459-4.434, p < 0.001). Conclusions: Our study demonstrated that high expression of EEF1A1 has a favorable prognostic effect on patients with colon adenocarcinoma.
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