Function of NADPH Oxidases in Diabetic Nephropathy and Development of Nox Inhibitors
- 주제(키워드) NADPH oxidase , Oxidative stress , Signal transduction , Kidney , Diabetic nephropathy , Nox inhibitor
- 주제(기타) Biochemistry & Molecular Biology; Pharmacology & Pharmacy
- 설명문(일반) [Lee, Sae Rom; An, Eun Jung; Kim, Jaesang; Bae, Yun Soo] Ewha Womans Univ, Dept Life Sci, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 Green Published
- 발행기관 KOREAN SOC APPLIED PHARMACOLOGY
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000165962
- 본문언어 영어
- Published As http://dx.doi.org/10.4062/biomolther.2019.188
- PubMed https://pubmed.ncbi.nlm.nih.gov/31875663
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Several recent studies have reported that reactive oxygen species (ROS), superoxide anion and hydrogen peroxide (H2O2), play important roles in various cellular signaling networks. NADPH oxidase (Nox) isozymes have been shown to mediate receptormediated ROS generation for physiological signaling processes involved in cell growth, differentiation, apoptosis, and fibrosis. Detectable intracellular levels of ROS can be induced by the electron leakage from mitochondrial respiratory chain as well as by activation of cytochrome p450, glucose oxidase and xanthine oxidase, leading to oxidative stress. The up-regulation and the hyper-activation of NADPH oxidases (Nox) also likely contribute to oxidative stress in pathophysiologic stages. Elevation of the renal ROS level through hyperglycemia-mediated Nox activation results in the oxidative stress which induces a damage to kidney tissues, causing to diabetic nephropathy (DN). Nox inhibitors are currently being developed as the therapeutics of DN. In this review, we summarize Nox-mediated ROS generation and development of Nox inhibitors for therapeutics of DN treatment.
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