Physiologic intestinal F-18-FDG uptake is associated with alteration of gut microbiota and proinflammatory cytokine levels in breast cancer
- 주제(기타) Multidisciplinary Sciences
- 설명문(일반) [Yoon, Hai-Jeon; Kim, Han-Na; Bang, Ji-In; Kim, Bom Sahn] Ewha Womans Univ, Sch Med, Dept Nucl Med, Seoul, South Korea; [Kim, Han-Na] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Med Res Inst, Seoul, South Korea; [Kim, Han-Na] Sungkyunkwan Univ, SAIHST, Dept Clin Res Design & Evaluat, Seoul, South Korea; [Lim, Woosung; Moon, Byung In; Paik, Nam Sun] Ewha Womans Univ, Sch Med, Mokdong Hosp, Dept Surg, Seoul, South Korea; [Kim, Hyung-Lae] Ewha Womans Univ, Sch Med, Dept Biochem, Seoul, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 NATURE PUBLISHING GROUP
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000166034
- 본문언어 영어
- Published As http://dx.doi.org/10.1038/s41598-019-54680-3
- PubMed https://pubmed.ncbi.nlm.nih.gov/31797893
초록/요약
The clinical significance of physiologic Fluorine-18-fluorodeoxyglucose (F-18-FDG) intestinal uptake (IU) based on the predicted link with gut microbiota dysbiosis and inflammatory cytokine production was investigated in a cohort of breast cancer patients. A total of 114 patients were visually classified into the lower or higher IU group. The maximum and mean standardized uptake values of total bowel (TB SUVmax and TB SUVmean) were measured. The gut microbial abundance of the Citrobacter genus of the Enterobacteriaceae family showed a significant positive correlation with TB SUVmax and TB SUVmean (q= 0.021 and q= 0.010). The unclassified Ruminococcaceae showed a significant negative correlation with TB SUVmax (q = 0.010). The level of tumor necrosis factor alpha (TNF-alpha) was significantly increased in the high IU group (p = 0.017). The TNF-alpha levels showed a significant positive correlation with TB SUVmax (rho = 0.220 and p= 0.018) and TB SUVmean (rho = 0.250 and p = 0.007). Therefore, our findings suggest that the physiologic intestinal uptake may reflect subclinical inflammation and differences in the composition of the gut microbiome in breast cancer patients.
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