Brief stress impairs recognition memory through amygdalar activation in animals with medial prefrontal cortex lesions
- 주제(키워드) Amygdala , c-Fos , Medial prefrontal cortex , Recognition memory , Stress
- 등재 SCIE, SCOPUS
- 발행기관 Elsevier Ireland Ltd
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000168695
- 본문언어 영어
- Published As https://dx.doi.org/10.1016/j.neulet.2020.135245
- PubMed https://pubmed.ncbi.nlm.nih.gov/32652210
초록/요약
The medial prefrontal cortex (mPFC) is thought to exert inhibitory control over stress-induced activation of the amygdala and neurocognitive effects. As evidence to support this, we examined how exposure to either a brief or prolonged stress affected on amygdalar c-Fos levels and recognition memory of animals with mPFC chemical lesions. mPFC-lesioned and sham-operated animals were subjected to either a brief 20-min restraint+20 tailshocks or a prolonged 60-min restraint+60 tailshocks. Post-stress performances in the object recognition memory and c-Fos immunoreactivity in the amygdala were then assessed. In sham-operated animals, the object recognition memory was reliably impaired following the prolonged, but not following the brief stress exposure. On the other hand, in mPFC-lesioned animals, the brief stress significantly impaired recognition memory and enhanced c-Fos expression in the amygdala. Present findings of loss of mPFC activity exacerbating stress effects provide causal evidence that the mPFC exerts inhibitory control on stress. © 2020 Elsevier B.V.
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