The Autophagy Regulator p62 Controls PTEN-Dependent Ciliogenesis
- 주제(키워드) autophagy , cilia , ciliogenesis , SQSTM1 , p62 , PTEN
- 주제(기타) Cell Biology
- 주제(기타) Developmental Biology
- 설명문(일반) [Mun, Hyowon; Lee, Eun Ji; Park, Minah; Park, Jong Hoon] Sookmyung Womens Univ, Dept Biol Sci, Seoul, South Korea; [Oh, Goo Taeg] Ewha Womans Univ, Dept Biol, Seoul, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 FRONTIERS MEDIA SA
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000168765
- 본문언어 영어
- Published As https://dx.doi.org/10.3389/fcell.2020.00465
- PubMed https://pubmed.ncbi.nlm.nih.gov/32587859
초록/요약
Autophagy is a catabolic process required for maintaining intracellular energy homeostasis. It eliminates harmful proteins and recycles functional macromolecules back into the cell via cargo breakdown. Autophagy is generally suppressed under fed conditions and induced by serum starvation; therefore, it is considered to be a nutrient-sensing mechanism. Cilia, finger-like organelles harboring multiple receptors along their surface, are energy-sensing structures that are also triggered by serum deprivation. Herein, we verified the effect of autophagy alterations on cilia assembly and the specific underlying mechanisms. Autophagy flux altered either by drugs or autophagy-targeting siRNAs strongly inhibited ciliogenesis, and this inhibition was affected by p62, an autophagy regulator, via Pten/Dvl2/AurKA signaling.
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