Mulberry Fruit Extract Ameliorates Adipogenesis via Increasing AMPK Activity and Downregulating MicroRNA-21/143 in 3T3-L1 Adipocytes
- 주제(키워드) adipogenesis , AMPK , microRNA-21 , 143 , mulberry fruit extract
- 주제(기타) Chemistry, Medicinal
- 주제(기타) Food Science & Technology
- 주제(기타) Nutrition & Dietetics
- 설명문(일반) [Lee, Mak-Soon; Kim, Yangha] Ewha Womans Univ, Dept Nutr Sci & Food Management, 52 Ewhayeodae Gil, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 MARY ANN LIEBERT, INC
- 발행년도 2020
- URI http://www.dcollection.net/handler/ewha/000000168847
- 본문언어 영어
- Published As https://dx.doi.org/10.1089/jmf.2019.4654
- PubMed https://pubmed.ncbi.nlm.nih.gov/32191574
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Mulberry (Morus alba L.) fruits have long been used in traditional medicine and as edible berries in many countries. This study investigated the antiadipogenic effect of high hydrostatic pressure mulberry fruit extract (MFE) during 3T3-L1 adipocyte differentiation. MFE decreased lipid and triglyceride accumulation and glycerol-3-phosphate dehydrogenase activity. The mRNA expression levels of genes related to adipogenesis, such as the adipocyte protein 2, proliferator-activated receptor-gamma, and CCAAT/enhancer binding protein-alpha, were suppressed by MFE. They also reduced microRNA (miR)-21 and miR-143 expression, which are involved in adipogenesis. In contrast, adenosine monophosphate-activated protein kinase (AMPK) activity was increased by MFE. These results suggested that MFE may suppress adipogenesis through modulating miR-21/143 expression and AMPK activity in 3T3-L1 adipocytes, which may be useful as antiobesity food agents.
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