A Systems Biological Approach to Understanding the Mechanisms Underlying the Therapeutic Potential of Red Ginseng Supplements against Metabolic Diseases
- 주제(키워드) metabolic disease , network analysis , Panax ginseng , red ginseng , systems biology
- 주제(기타) Biochemistry & Molecular Biology
- 주제(기타) Chemistry, Multidisciplinary
- 설명문(일반) [Jeong, Eunseon; Kim, Ji Yeon] Seoul Natl Univ Sci & Technol, Dept Food Sci & Technol, Seoul 01811, South Korea; [Lim, Yeni; Kwon, Oran] Ewha Womans Univ, Dept Nutr Sci & Food Management, Seoul 03760, South Korea; [Kim, Kyeong Jin; Kim, Ji Yeon] Seoul Natl Univ Sci & Technol, Dept Nano Bio Engn, Seoul 01811, South Korea; [Ki, Hyeon-Hui; Lee, Doheon] Biosynergy Res Ctr, Daejeon 34141, South Korea; [Lee, Doheon] Korea Adv Inst Sci & Technol KAIST, Dept Bio & Brain Engn, Daejeon 34141, South Korea; [Suh, Jaehyun; So, Seung-Ho] Korea Ginseng Corp, R&D Headquarter, Daejeon 34128, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 MDPI
- 발행년도 2020
- URI http://www.dcollection.net/handler/ewha/000000168853
- 본문언어 영어
- Published As https://dx.doi.org/10.3390/molecules25081967
- PubMed https://pubmed.ncbi.nlm.nih.gov/32340247
초록/요약
Red ginseng has been widely used in health-promoting supplements in Asia and is becoming increasingly popular in Western countries. However, its therapeutic mechanisms against most diseases have not been clearly elucidated. The aim of the present study was to provide the biological mechanisms of red ginseng against various metabolic diseases. We used a systems biological approach to comprehensively identify the component-target and target-pathway networks in order to explore the mechanisms underlying the therapeutic potential of red ginseng against metabolic diseases. Of the 23 components of red ginseng with target, 5 components were linked with 37 target molecules. Systematic analysis of the constructed networks revealed that these 37 targets were mainly involved in 9 signaling pathways relating to immune cell differentiation and vascular health. These results successfully explained the mechanisms underlying the efficiency of red ginseng for metabolic diseases, such as menopausal symptoms in women, blood circulation, diabetes mellitus, and hyperlipidemia.
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