Inhibitory Effects of Furanocoumarins From the Roots of Angelica dahurica on Ionizing Radiation-Induced Migration of A549 Human Non-Small Cell Lung Cancer Cells
- 주제(키워드) Angelica dahurica , apiaceae , furanocoumarin , radiation-induced migration , non-small-cell lung cancer cells
- 주제(기타) Chemistry, Medicinal
- 주제(기타) Food Science & Technology
- 설명문(일반) [Lee, Sang Hoon] Jaseng Med Fdn, Jaseng Spine & Joint Res Inst, Seoul, South Korea; [Han, Ah-Reum; Kim, Jin-Baek] Korea Atom Energy Res Inst, Adv Radiat Technol Inst, Jeongeup Si, Jeollabuk Do, South Korea; [Kang, Unwoo; Seo, Eun Kyoung] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Coll Pharm, Seoul 03760, South Korea; [Jung, Chan-Hun] Jeonju AgrobioMat Inst, Jeonju Si 54810, Jeollabuk Do, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold
- 발행기관 SAGE PUBLICATIONS INC
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000168883
- 본문언어 영어
- Published As https://dx.doi.org/10.1177/1934578X20915036
초록/요약
Radiation therapy is a very effective tool for the treatment of advanced human lung cancers. However, as one of its malignancy-promoting behaviors, ionizing radiation (IR) increases cell migration and radiation resistance in several lung cancer cells, including non-small cell lung cancer (NSCLC) cells. As part of our ongoing search for potent radiotherapy enhancers from medicinal herbs, a chloroform-soluble fraction of the roots of Angelica dahurica was subjected to phytochemical investigation, leading to the isolation of 8 furanocoumarins. Of these, psoralen (1), xanthotoxin (2), and bergapten (3) inhibited IR-induced migration at a non-cytotoxic concentration (50 mu M) in human NSCLC A549 cells. This study is the first to report on the inhibitory activities of these constituents of A. dahurica against IR-induced cancer metastasis.
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