Recent Insights Into SREBP as a Direct Mediator of Kidney Fibrosis via Lipid-Independent Pathways
- 주제(키워드) SREBP , TGF beta , lipotoxicity , renal lipid , kidney fibrosis
- 주제(기타) Pharmacology & Pharmacy
- 설명문(일반) [Dorotea, Debra; Ha, Hunjoo] Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, Seoul, South Korea; [Koya, Daisuke] Kanazawa Med Univ, Dept Internal Med, Uchinada, Ishikawa, Japan
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 FRONTIERS MEDIA SA
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000168890
- 본문언어 영어
- Published As https://dx.doi.org/10.3389/fphar.2020.00265
- PubMed https://pubmed.ncbi.nlm.nih.gov/32256356
초록/요약
Sterol regulatory-element binding proteins (SREBPs) are classical regulators of cellular lipid metabolism in the kidney and other tissues. SREBPs are currently recognized as versatile transcription factors involved in a myriad of cellular processes. Meanwhile, SREBPs have been recognized to mediate lipotoxicity, contributing to the progression of kidney diseases. SREBP1 has been shown to bind to the promoter region of TGF beta, a major pro-fibrotic signaling mechanism in the kidney. Conversely, TGF beta activates SREBP1 transcriptional activity suggesting a positive feedback loop of SREBP1 in TGF beta signaling. Public ChIP-seq data revealed numerous non-lipid transcriptional targets of SREBPs that plausibly play roles in progressive kidney disease and fibrosis. This review provides new insights into SREBP as a mediator of kidney fibrosis via lipid-independent pathways.
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