Fyn Kinase: A Potential Therapeutic Target in Acute Kidney Injury
- 주제(키워드) Fyn kinase , Acute kidney injury , Inflammation , Oxidative stress , ER stress , Autophagy
- 주제(기타) Biochemistry & Molecular Biology
- 주제(기타) Pharmacology & Pharmacy
- 설명문(일반) [Uddin, Md Jamal; Dorotea, Debra; Pak, Eun Seon; Ha, Hunjoo] Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 Green Published
- 발행기관 KOREAN SOC APPLIED PHARMACOLOGY
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000168891
- 본문언어 영어
- Published As https://dx.doi.org/10.4062/biomolther.2019.214
- PubMed https://pubmed.ncbi.nlm.nih.gov/32336052
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Acute kidney injury (AKI) is a common disease with a complex pathophysiology which significantly contributes to the development of chronic kidney disease and end stage kidney failure. Preventing AKI can consequently reduce mortality, morbidity, and health-care burden. However, there are no effective drugs in use for either prevention or treatment of AKI. Developing therapeutic agents with pleiotropic effects covering multiple pathophysiological pathways are likely to be more effective in attenuating AKI. Fyn, a non-receptor tyrosine kinase, has been acknowledged to integrate multiple injurious stimuli in the kidney. Limited studies have shown increased Fyn transcription level and activation under experimental AKI. Activated Fyn kinase propagates various downstream signaling pathways associated to the progression of AKI, such as oxidative stress, inflammation, endoplasmic reticulum stress, as well as autophagy dysfunction. The versatility of Fyn kinase in mediating various pathophysiological pathways suggests that its inhibition can be a potential strategy in attenuating AKI.
more