Evaluation of Anti-Tumor Effects of Whole-Body Low-Dose Irradiation in Metastatic Mouse Models
- 주제(키워드) irradiation , systemic immune response , epithelial-mesenchymal transition , metastasis , abscopal effect
- 주제(기타) Oncology
- 설명문(일반) [Song, Kyung-Hee; Jung, Seung-Youn; Park, Jeong-In; Ahn, Jiyeon; Park, Jong-Kuk; Hwang, Sang-Gu; Kim, Eun-Ho; Song, Jie-Young] Korea Inst Radiol & Med Sci, Div Radiat Biomed Res, Seoul 01812, South Korea; [Song, Kyung-Hee; Ha, Hunjoo] Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea; [Kim, Eun-Ho] Daegu Catholic Univ, Sch Med, Dept Biochem, Daegu 42472, South Korea; [Nam, Seon Young] Korea Hydro & Nucl Power Co Ltd, Radiat Hlth Inst, Low Dose Radiat Res Team, Seoul 01450, South Korea; [Park, Seungwoo] Korea Inst Radiol & Med Sci, Div Med Radiat Equipment, Seoul 01812, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 MDPI
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000168892
- 본문언어 영어
- Published As https://dx.doi.org/10.3390/cancers12051126
- PubMed https://pubmed.ncbi.nlm.nih.gov/32365904
초록/요약
Low-dose irradiation (LDI) has recently been shown to have various beneficial effects on human health, such as on cellular metabolic activities, DNA repair, antioxidant activity, homeostasis potency, and immune activation. Although studies on the immunogenic effects of LDI are rapidly accumulating, clinical trials for cancer treatment are considered premature owing to the lack of available preclinical results and protocols. Here, we aim to investigate anti-tumor and anti-metastatic effects of whole-body LDI in several tumor-bearing mouse models. Mice were exposed to single or fractionated whole-body LDI prior to tumor transplantation, and tumor growth and metastatic potential were determined, along with analysis of immune cell populations and expression of epithelial-mesenchymal transition (EMT) markers. Whole-body fractionated-LDI decreased tumor development and lung metastasis not only by infiltration of CD4(+), CD8(+) T-cells, and dendritic cells (DCs) but also by attenuating EMT. Moreover, a combination of whole-body LDI with localized high-dose radiation therapy reduced the non-irradiated abscopal tumor growth and increased infiltration of effector T cells and DCs. Therefore, whole-body LDI in combination with high-dose radiation therapy could be a potential therapeutic strategy for treating cancer.
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