Effects of Citrulline Supplementation on Body Weight in Patients With Hepatobiliary Pancreatic Surgery
- 주제(키워드) body weight , citrulline , hepatobiliary surgery , pancreatic surgery
- 등재 SCIE, SCOPUS
- 발행기관 John Wiley and Sons Inc.
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000168895
- 본문언어 영어
- Published As https://dx.doi.org/10.1002/ncp.10395
- PubMed https://pubmed.ncbi.nlm.nih.gov/31606911
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Background: Many health benefits have been proposed for citrulline, but they lack evidence based on human research. This study was to evaluate whether an oral citrulline supplement affects body weight changes and laboratory values in patients with hepatobiliary and pancreatic surgery. Methods: Patients who underwent hepatobiliary and pancreatic surgery during January to June 2015 were screened for analysis. Patients using citrulline during hospital stay and at discharge were classified as the citrulline group, whereas those without any records of citrulline were designated as the control group. The primary efficacy outcome was the change in body weight at discharge and at first outpatient visit. Other outcomes included change in laboratory values. Results: A total of 138 patients were included in analysis. Citrulline group and control group did not differ with respect to baseline characteristics except for white blood cell count. Percent in change of body weight and body mass index from discharge to first outpatient visit was significantly different between the 2 groups, showing less weight loss in citrulline group than in controls (−0.8 ± 2.7% vs −2.5 ± 3.8%, P < 0.05). Especially in men, citrulline use significantly affected weight loss from the multivariate analysis (P < 0.05); percent change in weight in citrulline group was predicted to increase by 2.1 units. During hospital stay, significant differences between the 2 groups were found in changes of cholesterol and protein levels. Conclusion: Citrulline supplement reduced weight loss in surgical patients during recovery. © 2019 American Society for Parenteral and Enteral Nutrition
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