Asymmetric Total Syntheses of Kopsane Alkaloids via a PtCl2-Catalyzed Intramolecular [3+2] Cycloaddition
- 주제(키워드) alkaloids , kopsanes , natural products , Pt catalysis , [3+2] cycloaddition reactions
- 등재 SCOPUS
- 발행기관 Wiley-Blackwell
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000168912
- 본문언어 영어
- Published As https://dx.doi.org/10.1002/ange.202005048
초록/요약
A concise and asymmetric total synthesis of five kopsane alkaloids that share a unique heptacyclic caged ring system was accomplished. The key transformation in the sequence involved a remarkable PtCl2-catalyzed intramolecular [3+2] cycloaddition, which allowed for the rapid assembly of pentacyclic carbon skeletons bearing 2,3-quaternary functionalized indoline. Expeditious construction of diverse indoline scaffolds with excellent control of diastereoselectivity demonstrated the broad scope and versatility of this key transformation. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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