A Copper(I)-Mediated Tandem Three-Component Synthesis of 5-Allyl-1,2,3-triazoles
- 주제(키워드) 1 , 2 , 3-triazoles , click reactions , copper catalyst , multicomponent reactions , one-pot reactions
- 등재 SCIE, SCOPUS
- 발행기관 Georg Thieme Verlag
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000168913
- 본문언어 영어
- Published As https://dx.doi.org/10.1055/s-0039-1691506
초록/요약
A copper(I)-mediated tandem three-component reaction using alkynes, azides, allyl iodides, CuI and NaNH 2 is developed. The reactions proceed smoothly at room temperature to afford 5-allyl-1,2,3-triazoles, which can be further converted into 1,2,3-triazole-fused tricyclic scaffolds. This method features an efficient one-pot cascade route using commercial alkynes and affords the corresponding 5-allyl-1,2,3-triazoles with high yields and good selectivity under mild reaction conditions. © 2020 Georg Thieme Verlag. All rights reserved.
more