Adjuvant incorporated lipid nanoparticles for enhanced mRNA-mediated cancer immunotherapy
- 주제(기타) Materials Science, Biomaterials
- 설명문(일반) [Lee, Kyuri; Kim, Soo Young; Seo, Yunmi; Kim, Myung Hee; Chang, Jun; Lee, Hyukjin] Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 ROYAL SOC CHEMISTRY
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000168914
- 본문언어 영어
- Published As https://dx.doi.org/10.1039/c9bm01564g
- PubMed https://pubmed.ncbi.nlm.nih.gov/31793928
초록/요약
For mRNA mediated cancer immunotherapy, Pam3 was incorporated as an adjuvant within lipid nanoparticles (LNPs) with OVA mRNA. The developed Pam3 incorporated LNPs showed successful expression of tumor antigens with enhanced immune stimulation. We demonstrated that the synergies of Pam3 LNPs could greatly improve the efficacy of tumor prevention by mRNA vaccines.
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