Environmental pollutants affecting children's growth and development: Collective results from the MOCEH study, a multi-centric prospective birth cohort in Korea
- 주제(키워드) Birth cohort , Children Environmental health , Environmental pollutants
- 주제(기타) Environmental Sciences
- 설명문(일반) [Shah, Surabhi; Park, Eun-Kyo; Ha, Eunhee] Ewha Womans Univ, Coll Med, Ewha Med Res Ctr, Dept Occupat & Environm Med, Seoul, South Korea; [Jeong, Kyoung Sook] Hallym Univ, Dept Occupat & Environm Med, Sacred Heart Hosp, Anyang, South Korea; [Park, Hyesook; Park, Bohyun] Ewha Womans Univ, Coll Med, Ewha Med Res Ctr, Dept Prevent Med, Seoul, South Korea; [Hong, Yun-Chul] Seoul Natl Univ, Dept Prevent Med, Coll Med, Seoul, South Korea; [Kim, Yangho] Univ Ulsan, Ulsan Univ Hosp, Dept Occupat & Environm Med, Coll Med, Ulsan, South Korea; [Kim, Byungmi] Natl Canc Ctr, Natl Canc Control Inst, Div Canc Prevent & Early Detect, Goyang, South Korea; [Chang, Namsoo] Ewha Womans Univ, Dept Nutr Sci & Food Management, Seoul, South Korea; [Kim, Suejin] Natl Inst Environm Res, Humidifier Disinfectant Hlth Ctr, Incheon, South Korea; [Kim, Yeni] Natl Ctr Mental Hlth, Dept Child & Adolescent Psychiat, Seoul, South Korea; [Kim, Yeni] Dongguk Univ Int Hosp, Dept Psychiat, Goyang, South Korea; [Kim, Bung-Nyun] Seoul Natl Univ, Dept Psychiat, Div Child & Adolescent Psychiat, Coll Med, Seoul, South Korea; [Kim, Bung-Nyun] Seoul Natl Univ, Inst Human Behav Med, Coll Med, Seoul, South Korea; [Kwon, Hojang; Joo, Hyunjoo; Ha, Mina] Dankook Univ, Coll Med, Dept Prevent Med, Cheonan, South Korea; [Bae, Sanghyuk] Catholic Univ Korea, Dept Prevent Med, Seoul, South Korea; [Kim, Hwan-Cheol; Leem, Jong-Han] Inha Univ, Dept Social & Prevent Med, Coll Med, Incheon, South Korea; [Kim, Hwan-Cheol; Leem, Jong-Han] Inha Univ Hosp, Dept Occupat & Environm Med, Incheon, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold
- 발행기관 PERGAMON-ELSEVIER SCIENCE LTD
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000169128
- 본문언어 영어
- Published As https://dx.doi.org/10.1016/j.envint.2020.105547
- PubMed https://pubmed.ncbi.nlm.nih.gov/32088541
초록/요약
Background: The Mothers and Children's Environmental Health study (MOCEH) is a multi-centric prospective birth cohort study investigating effects of various environmental pollutants like heavy metals, endocrine disruptors, air pollutants, nutrition and lifestyle on birth outcomes, growth and development, health and disease of children. In this study, we report all the outcomes from the MOCEH study describing the different environmental pollutants affecting children's health and disease. Methods: In MOCEH study, 1,751 pregnant women in their first trimester were recruited at 3 centers from 2006 to 2010 in South Korea. The children were followed from birth up to 6 years. Information on health outcomes of children including birth parameters, demographic characteristics, medical and child-rearing history, and nutritional status, were repeatedly obtained through the follow-ups by questionnaires administration, clinical evaluation, and biological specimen collection and measurements. Prenatal and postnatal measurement in biospecimen, i.e., lead, mercury, cadmium, manganese, 1-hydroxypyrene, 2-naphthol, malonadialdehyde, hippuric acid, bisphenol A and phthalate metabolites, and measurement in air samples, i.e., particulate matter, nitrogen dioxide, and total volatile organic compounds were performed. Results: The results show the adverse effect of prenatal exposure to heavy metals like mercury, lead and cadmium on children's physical, cognitive and neurobehavioral development. Exposure to endocrine disruptors, air pollution, second hand smoke, and mother's lifestyle during pregnancy affects children's growth and development. We also identified specific window periods of exposure of pollutants significantly related to children's health outcomes. Conclusion: The collective results from MOCEH study provide strong scientific evidence that exposures to prenatal and postnatal environmental pollutants have a negative effect on growth and development of children, which will be useful in implementing effective national policy to improve children's environmental health.
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