The Relationship between Serum Vitamin D Levels, C-Reactive Protein, and Anxiety Symptoms
- 주제(키워드) Vitamin D , CRP , Anxiety
- 주제(기타) Psychiatry
- 설명문(일반) [Kim, Sun-Young; Lim, Weon-Jeong] Ewha Womans Univ, Seoul Hosp, Dept Psychiat, Coll Med, Seoul, South Korea; [Jeon, Sang-Won; Oh, Kang-Seob; Shin, Dong-Won; Cho, Sung Joon; Shin, Young-Chul] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Psychiat, Sch Med, 29 Saemunan Ro, Seoul 03181, South Korea; [Jeon, Sang-Won; Cho, Sung Joon; Shin, Young-Chul] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Workpl Mental Hlth Inst, Sch Med, Seoul, South Korea; [Park, Jae-Hyun] Sungkyunkwan Univ, Dept Social & Prevent Med, Sch Med, Suwon, South Korea
- 등재 SCIE, SSCI, SCOPUS, KCI등재
- OA유형 Green Published, gold
- 발행기관 KOREAN NEUROPSYCHIATRIC ASSOC
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000169169
- 본문언어 영어
- Published As https://dx.doi.org/10.30773/pi.2019.0290
- PubMed https://pubmed.ncbi.nlm.nih.gov/32213801
초록/요약
Objective The aim of study is to investigate the relationship between serum vitamin D, c-reactive protein (CRP) levels, and anxiety symptoms. Methods Serum vitamin D and CRP levels of 51,003 Korean adult participants were collected retrospectively. Anxiety symptoms were assessed using the Korean version of Beck Anxiety Inventory. Logistic regression was used to estimate the odds ratio (ORs) of anxiety symptoms by serum vitamin D and CRP levels. The regression was adjusted for covariates, and each model was adjusted mutually for vitamin D and CRP levels. Results Compared with sufficient vitamin D levels (>= 20 ng/mL), insufficient (10-19.99 ng/mL) and deficient (<10 ng/mL) vitamin D levels were significantly associated with risk of anxiety symptoms. Also, continuous vitamin D levels were negatively associated with the risk of anxiety symptoms. CRP levels did not affect the relationship between vitamin D levels and risk of anxiety symptoms. Conclusion Insufficient (10-19.99 ng/mL) and deficient (<10 ng/mL) vitamin D levels were significantly associated with risk of anxiety symptoms. After adjusting for CRP levels, the results were not changed, and no evidence of interaction between vitamin D and CRP levels was found. CRP levels did not account for the association between vitamin D levels and risk of anxiety symptoms.
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