Korean Red Ginseng prevents posttraumatic stress disorder-triggered depression-like behaviors in rats via activation of the serotonergic system
- 주제(키워드) depression , Korean Red Ginseng , posttraumatic stress disorder , single prolonged stress , serotonin
- 주제(기타) Plant Sciences
- 주제(기타) Chemistry, Medicinal
- 주제(기타) Integrative & Complementary Medicine
- 설명문(일반) [Lee, Bombi; Lee, Hyejung] Kyung Hee Univ, Coll Korean Med, Acupuncture & Meridian Sci Res Ctr, 26 Kyungheedae Ro, Seoul 02447, South Korea; [Lee, Bombi] Kyung Hee Univ, Ctr Converging Humanities, Seoul, South Korea; [Sur, Bongjun; Oh, Seikwan] Ewha Womans Univ, Sch Med, Dept Mol Med & TIDRC, Seoul 07985, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 gold, Green Published
- 발행기관 KOREAN SOC GINSENG
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000169178
- 본문언어 영어
- Published As https://dx.doi.org/10.1016/j.jgr.2019.09.005
- PubMed https://pubmed.ncbi.nlm.nih.gov/32617045
초록/요약
Background: Posttraumatic stress disorder (PTSD), a mental disorder induced by traumatic stress and often accompanied by depression and/or anxiety, may involve an imbalance in the neurotransmitters associated with the fear response. Korean Red Ginseng (KRG) has long been used as a traditional medicine and is known to be involved in a variety of pharmacological activities. We used the open field test and forced swimming test to examine the effects of KRG on the depression-like response of rats after exposure to single prolonged stress (SPS), leading to activation of the serotonergic system. Methods: Male rats received KRG (30, 50, and 100 mg/kg, intraperitoneal injection) once daily for 14 days after exposure to SPS. Results: Daily KRG administration significantly improved depression-like behaviors in the forced swimming test, increased the number of lines crossed and time spent in the central zone in the open field test, and decreased freezing behavior in contextual and cued fear conditioning. KRG treatment attenuated SPS-induced decreases in serotonin (5-HT) tissue concentrations in the hippocampus and medial prefrontal cortex. The increased 5-HT concentration during KRG treatment may be partially attributable to the 5-hydroxyindoleacetic acid/5-HT ratio in the hippocampus of rats with PTSD. These effects may be caused by the activation of hippocampal genes encoding tryptophan hydroxylase-1 and 2 mRNA levels. Conclusion: Our findings suggest that KRG has an antidepressant effect in rats subjected to SPS and may represent an effective use of traditional medicine for the treatment of PTSD. (C) 2019 The Korean Society of Ginseng. Publishing services by Elsevier B.V.
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