Telomere shortening reflecting physical aging is associated with cognitive decline and dementia conversion in mild cognitive impairment due to Alzheimer's disease
- 주제(키워드) Alzheimer's disease , mild cognitive impairment , telomere , progression , amyloid
- 주제(기타) Cell Biology
- 주제(기타) Geriatrics & Gerontology
- 설명문(일반) [Koh, Seong-Ho; Park, Hyun-Hee; Ha, Jungsoon] Hanyang Univ, Dept Neurol, Coll Med, Guri 11923, South Korea; [Choi, Seong Hye] Inha Univ, Dept Neurol, Sch Med, Incheon 22332, South Korea; [Jeong, Jee Hyang] Ewha Womans Univ, Dept Neurol, Sch Med, Seoul 07985, South Korea; [Jang, Jae-Won] Kangwon Natl Univ, Dept Neurol, Sch Med, Chunchon 24289, South Korea; [Park, Kyung Won] Dong A Univ, Dong A Med Ctr, Dept Neurol, Coll Med, Busan 49201, South Korea; [Kim, Eun-Joo] Pusan Natl Univ, Pusan Natl Univ Hosp, Dept Neurol, Sch Med, Busan 49241, South Korea; [Kim, Eun-Joo] Med Res Inst, Busan 49241, South Korea; [Kim, Hee Jin] Sungkyunkwan Univ, Samsung Med Ctr, Dept Neurol, Sch Med, Seoul 06351, South Korea; [Hong, Jin Yong] Yonsei Univ, Dept Neurol, Wonju Coll Med, Wonju 26426, South Korea; [Yoon, Soo Jin] Eulji Univ, Eulji Univ Hosp, Dept Neurol, Sch Med, Daejeon 35233, South Korea; [Yoon, Bora] Konyang Univ, Dept Neurol, Coll Med, Daejeon 35365, South Korea; [Kang, Ju-Hee] Inha Univ, Dept Pharmacol, Sch Med, Incheon 22212, South Korea; [Lee, Jong-Min] Hanyang Univ, Dept Biomed Engn, Seoul 04763, South Korea; [Ha, Jungsoon] GemVax & Kael Co Ltd, Seongnam 13461, South Korea; [Suh, Young Ju] Inha Univ, Dept Biomed Sci, Sch Med, Incheon 22332, South Korea; [Kang, Suyeon] Inha Univ, Dept Stat, Incheon 22212, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 IMPACT JOURNALS LLC
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000169272
- 본문언어 영어
- Published As https://dx.doi.org/10.18632/aging.102893
- PubMed https://pubmed.ncbi.nlm.nih.gov/32126022
초록/요약
We investigated whether telomere length (TL) reflecting physical rather than chronological aging is associated with disease progression in the different cognitive stages of Alzheimer's disease (AD). Study participants included 89 subjects with amyloid pathology (A+), determined through amyloid PET or cerebrospinal fluid analysis, including 26 cognitively unimpaired (CU A+) individuals, 28 subjects with mild cognitive impairment (MCI A+), and 35 subjects with AD dementia (ADD A+). As controls, 104 CU A- individuals were selected. The participants were evaluated annually over two years from baseline. Compared to the highest TL quartile group of MCI A+ participants, the lowest TL quartile group yielded 2-year differences of -9.438 (95% confidence interval [CI] = -14.567 (similar to) -4.309), -26.708 (-41.576 (similar to) -11.839), 3.198 (1.323 (similar to) 5.056), and 2.549 (0.527 (similar to) 4.571) on the Mini-Mental State Examination, Consortium to Establish a Registry for AD, Clinical Dementia Rating-Sum of Boxes, and Blessed Dementia Scale-Activities of Daily Living, respectively. With this group, the lowest TL quartile group had a significantly greater probability of progressing to ADD than the highest TL quartile group (hazard ratio = 13.16, 95% CI = 1.11 (similar to) 156.61). Telomere shortening may be associated with rapid cognitive decline and conversion to dementia in MCI A+.
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