South Korean Study to Prevent Cognitive Impairment and Protect Brain Health Through Lifestyle Intervention in At-Risk Elderly People: Protocol of a Multicenter, Randomized Controlled Feasibility Trial
- 주제(키워드) cognitive impairment , dementia , lifestyle , prevention , randomized controlled trial
- 주제(기타) Clinical Neurology
- 설명문(일반) [Park, Hee Kyung; Jeong, Jee Hyang] Ewha Womans Univ, Sch Med, Dept Neurol, Seoul, South Korea; [Moon, So Young; Lee, Sun Min] Ajou Univ, Sch Med, Dept Neurol, Suwon, South Korea; [Hong, Chang Hyung] Ajou Univ, Sch Med, Dept Psychiat, Suwon, South Korea; [Park, Yoo Kyoung] Kyung Hee Univ, Grad Sch East West Med Nutr, Dept Med Nutr, Suwon, South Korea; [Na, Hae Ri] Bobath Mem Hosp, Dept Neurol, Seongnam, South Korea; [Song, Hong-Sun; Chun, Buong-O] Korea Inst Sports Sci, Dept Sports Sci, Seoul, South Korea; [Choi, Muncheong] Kookmin Univ, Dept Phys Educ, Seoul, South Korea; [Park, Kyung Won] Dong A Univ, Dept Neurol, Coll Med, Busan, South Korea; [Kim, Byeong C.; Cho, Soo Hyun] Chonnam Natl Univ, Med Sch, Dept Neurol, Gwangju, South Korea; [Choi, Seong Hye] Inha Univ, Sch Med, Dept Neurol, Incheon, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 Green Published, gold
- 발행기관 KOREAN NEUROLOGICAL ASSOC
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000169273
- 본문언어 영어
- Published As https://dx.doi.org/10.3988/jcn.2020.16.2.292
- PubMed https://pubmed.ncbi.nlm.nih.gov/32319247
초록/요약
Background and Purpose The prevalence of dementia is increasing in South Korea. Multidomain interventions may be useful for preventing dementia. Such programs need to be disseminated to elderly Koreans throughout the country. We have developed programs of the SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN), which consists of a facility-based multidomain intervention (FMI) program and a home-based multidomain intervention (HMI) program suitable for elderly Koreans. We aim to determine the feasibility of the SUPERBRAIN programs before a large-scale randomized controlled trial. Methods We will recruit 150 participants among those without dementia aged 60-79 years with at least 1 modifiable dementia risk factor. They will be randomly assigned in a 1:1:1 ratio to the FMI, HMI, and the waiting-list control arm. The 6-month multidomain intervention consists of management of metabolic and vascular risk factors, cognitive training and social activity, physical exercise, nutritional guidance, and motivational enhancement programs. The primary outcomes are adherence and retention rates and changes in the total scale index score of the Repeatable Battery for the Assessment of Neuropsychological Status from baseline to the study end. The main secondary outcomes are disability, depressive symptoms, quality of life, vascular risk factors, physical performance, nutritional assessment, and motivation questionnaire. There will be an exploratory evaluation of neurotrophic, neurodegeneration, and neuroinflammation factors, microbiome, telomere length, electroencephalography, and neuroimaging measures. Conclusions The results obtained will provide information on the applicability of these multi domain intervention programs to at-risk elderly people.
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