Comparative Efficacy of Targeted Therapies in Patients with Non-Small Cell Lung Cancer: A Network Meta-Analysis of Clinical Trials
- 주제(키워드) non-small cell lung cancer , targeted therapy , network meta-analysis
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [Hoang, Tung; Myung, Seung-Kwon; Kim, Jeongseon] Natl Canc Ctr, Grad Sch Canc Sci & Policy, Dept Canc Biomed Sci, Goyang 10408, South Korea; [Myung, Seung-Kwon] Natl Canc Ctr, Res Inst, Div Canc Epidemiol & Management, Goyang 10408, South Korea; [Myung, Seung-Kwon] Natl Canc Ctr Hosp, Dept Family Med, Goyang 10408, South Korea; [Myung, Seung-Kwon] Natl Canc Ctr Hosp, Ctr Canc Prevent & Detect, Goyang 10408, South Korea; [Thu Thi Pham] Charite Univ Med Berlin, Inst Publ Hlth, Hlth Data Sci Program, D-10117 Berlin, Germany; [Thu Thi Pham] Max Delbruck Ctr Mol Med MDC, Mol Epidemiol Res Grp, D-13125 Berlin, Germany; [Ju, Woong] Ewha Womans Univ, Coll Med, Dept Obstet & Gynecol, Seoul 07804, South Korea; [Ju, Woong] Ewha Womans Univ, Coll Med, Med Res Inst, Seoul 07804, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Accepted, Green Published, gold
- 발행기관 MDPI
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000169277
- 본문언어 영어
- Published As https://dx.doi.org/10.3390/jcm9041063
- PubMed https://pubmed.ncbi.nlm.nih.gov/32283699
초록/요약
This study aims to investigate the efficacy of targeted therapies in the treatment of non-small cell lung cancer (NSCLC) by using a network meta-analysis of clinical trials. PubMed, EMBASE, Cochrane Library, and Clinicaltrials.gov were searched by using keywords related to the topic on 19 September 2018. Two investigators independently selected relevant trials by pre-determined criteria. A pooled response ratio (RR) for overall response rate (ORR) and a hazard ratio (HR) for progression-free survival (PFS) were calculated based on both the Bayesian and frequentist approaches. A total of 128 clinical trials with 39,501 participants were included in the final analysis of 14 therapeutic groups. Compared with chemotherapy, both ORR and PFS were significantly improved for afatinib, alectinib, and crizotinib, while only PFS was significantly improved for cabozantinib, ceritinib, gefitinib, and osimertinib. Consistency was observed between the direct and indirect comparisons based on the Bayesian approach statistically and the frequentist approach visually. Cabozantinib and alectinib showed the highest probability for the first-line treatment ranking in ORR (62.5%) and PFS (87.5%), respectively. The current network meta-analysis showed the comprehensive evidence-based comparative efficacy of different types of targeted therapies, which would help clinicians use targeted therapies in clinical practice.
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