Cervical Lymph Node Involvement above the Supraclavicular Fossa in Breast Cancer: Comparison with Stage IIIC (KROG 18-02)
- 주제(키워드) Breast , Carcinoma , Neoplasm metastasis , Survival , Neoplasm staging
- 주제(기타) Oncology
- 설명문(일반) [Kim, Jae Sik; Shin, Kyung Hwan; Kim, Jin Ho] Seoul Natl Univ, Dept Radiat Oncol, Coll Med, 101 Daehak Ro, Seoul 03080, South Korea; [Kim, Kyubo] Ewha Womans Univ, Dept Radiat Oncol, Coll Med, Seoul, South Korea; [Ahn, Seung Do; Kim, Su Ssan] Univ Ulsan, Asan Med Ctr, Dept Radiat Oncol, Coll Med, Seoul, South Korea; [Kim, Yong Bae; Chang, Jee Suk] Yonsei Univ, Yonsei Canc Ctr, Dept Radiat Oncol, Coll Med, Seoul, South Korea; [Choi, Doo Ho; Park, Won] Sungkyunkwan Univ, Samsung Med Ctr, Dept Radiat Oncol, Sch Med, Seoul, South Korea; [Kim, Tae Hyun] Natl Canc Ctr, Ctr Proton Therapy, Res Inst & Hosp, Goyang, South Korea; [Chun, Mison] Ajou Univ, Dept Radiat Oncol, Sch Med, Suwon, South Korea; [Cha, Jihye] Wonju Severance Christian Hosp, Dept Radiat Oncol, Wonju, South Korea; [Kim, Jin Hee] Keimyung Univ, Dongsan Med Ctr, Sch Med, Dept Radiat Oncol, Daegu, South Korea; [Lee, Dong Soo] Catholic Univ Korea, Uijeongbu St Marys Hosp, Dept Radiat Oncol, Uijongbu, South Korea; [Lee, Sun Young] Jeonbuk Natl Univ Hosp, Dept Radiat Oncol, Jeonju, South Korea; [Park, Hae Jin] Hanyang Univ, Dept Radiat Oncol, Coll Med, Seoul, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 Green Published, gold
- 발행기관 KOREAN BREAST CANCER SOC
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000169365
- 본문언어 영어
- Published As https://dx.doi.org/10.4048/jbc.2020.23.e14
- PubMed https://pubmed.ncbi.nlm.nih.gov/32395378
초록/요약
Purpose: We aimed to analyze the treatment outcomes of ipsilateral cervical lymph node (CLN)-positive breast cancer without other distant metastasis and compare the outcomes with those of supraclavicular lymph node (SCL)-positive breast cancer. Methods: Seventy-eight patients with breast cancer and ipsilateral CLN metastasis above the supraclavicular fossa (CLN[+] group) were treated at 7 institutions (2000-2014). Seventy-four patients received systemic chemotherapy and breast surgery followed by locoregional radiotherapy. Outcomes of the CLN(+) group were compared with those of the SCL(+) group, which included 183 patients with SCL involvement. Results: The median follow-up duration was 55.9 months. Twenty-two regional failures were found in 15 patients-axillary lymph node (LN) in 8, SCL in 6, internal mammary LN in 3, previously involved CLN in 4, and previously uninvolved ipsilateral CLN in one patient. The 5-year overall survival (OS), disease-free survival (DFS), locoregional relapse-free survival (LRRFS), and distant metastasis-free survival (DMFS) rates were 68.6%, 46.7%, 68.4%, and 57.0%, respectively. Neck dissection did not improve LRRFS and DFS (p= 0.86 and p= 0.26, respectively). Multivariate analysis showed that hormone receptor negativity and the presence of extracapsular extension were prognostic factors for poor DFS. On comparison with stage IIIC using propensity score matching, survival outcomes of the CLN(+) and SCL(+) groups were not different (5-year OS, p= 0.75; DFS, p= 0.88; LRRFS, p= 0.86; and DMFS, p = 0.45). Conclusion: The comparable clinical outcomes indicate that patients with breast cancer who have ipsilateral CLN metastasis without other distant metastasis may benefit from locoregional treatment of the ipsilateral breast and systemic therapies, as do those with N3c disease.
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