Molecular Design of Highly Efficient Heavy-Atom-Free Triplet BODIPY Derivatives for Photodynamic Therapy and Bioimaging
- 주제(키워드) aggregation-induced emission , BODIPY , heavy-atom-free photosensitizers , photodynamic therapy , reactive oxygen species
- 주제(기타) Chemistry, Multidisciplinary
- 설명문(일반) [Nguyen, Van-Nghia; Yim, Yubin; Swamy, K. M. K.; Kim, Gyoungmi; Kwon, Nahyun; Yoon, Juyoung] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 03760, South Korea; [Kim, Sangin; Park, Sungnam] Korea Univ, Dept Chem, Seoul 02841, South Korea; [Ryu, Bokyeong] Seoul Natl Univ, Dept Lab Anim Med, Coll Vet Med, Seoul 08826, South Korea; [Kim, C-Yoon] Konkuk Univ, Dept Stem Cell Biol, Sch Med, Seoul 05029, South Korea; [Swamy, K. M. K.] VL Coll Pharm, Dept Pharmaceut Chem, Raichur 584103, India
- 등재 SCIE, SCOPUS
- 발행기관 WILEY-V C H VERLAG GMBH
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000169502
- 본문언어 영어
- Published As https://dx.doi.org/10.1002/anie.202002843
- PubMed https://pubmed.ncbi.nlm.nih.gov/32125064
초록/요약
Novel BODIPY photosensitizers were developed for imaging-guided photodynamic therapy. The introduction of a strong electron donor to the BODIPY core through a phenyl linker combined with the twisted arrangement between the donor and the BODIPY acceptor is essential for reducing the energy gap between the lowest singlet excited state and the lowest triplet state (Delta E-ST), leading to a significant enhancement in the intersystem crossing (ISC) of the BODIPYs. Remarkably, the BDP-5 with the smallest Delta E-ST (ca. 0.44 eV) exhibited excellent singlet oxygen generation capabilities in both organic and aqueous solutions. BDP-5 also displayed bright emission in the far-red/near-infrared region in the condensed states. More importantly, both in vitro and in vivo studies demonstrated that BDP-5 NPs displayed a high potential for photodynamic cancer therapy and bioimaging.
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