A boronic acid-functionalized phthalocyanine with an aggregation-enhanced photodynamic effect for combating antibiotic-resistant bacteria
- 주제(기타) Chemistry, Multidisciplinary
- 설명문(일반) [Li, Xingshu] Fuzhou Univ, Fujian Prov Key Lab Canc Metastasis Chemoprevent, State Key Lab Photocatalysis Energy & Environm, Coll Chem, Fuzhou 350108, Peoples R China; [Lee, Eunhye; Kwon, Nahyun; Kim, Gyoungmi; Yoon, Juyoung] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 120750, South Korea; [Oh, Juwon; Kim, Dongho] Yonsei Univ, Dept Chem, Spect Lab Funct Elect Syst, Seoul 120749, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 ROYAL SOC CHEMISTRY
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000169504
- 본문언어 영어
- Published As https://dx.doi.org/10.1039/d0sc01351j
- PubMed https://pubmed.ncbi.nlm.nih.gov/32864085
초록/요약
Most existing photosensitizers (e.g., porphyrins) are often aggregated in aqueous solution because of their large conjugated molecular structures. This aggregation usually results in a lack or low levels of reactive oxygen species (ROS) generation due to aggregation-caused quenching, which severely hampers the application of photosensitizers in photodynamic therapy (PDT). Herein, we make an interesting finding that a boronic acid-functionalized phthalocyanine (PcN4-BA) displays an uncommon phenomenon, an aggregation-enhanced photodynamic effect. The combination of the ability to form uniform nanostructured self-assemblies in water, highly efficient ROS generation and boronic acid-induced targeting give PcN4-BA excellent performances in antimicrobial PDT.
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