Peptide-Driven Shape Control of Low-Dimensional DNA Nanostructures
- 주제(키워드) block copolymer , DNA , nanofiber , nanosheet , peptide , self-assembly
- 등재 SCIE, SCOPUS
- 발행기관 American Chemical Society
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000169546
- 본문언어 영어
- Published As https://dx.doi.org/10.1021/acsnano.9b09312
- PubMed https://pubmed.ncbi.nlm.nih.gov/31962047
초록/요약
We report the rational design and fabrication of unusual low-dimensional DNA nanostructures through programmable and sequence-specific peptide interactions. Dual-bioactive block copolymers composed of DNA and amino acid-based polymers (DNA-b-poly(amino acid)) were synthesized by coupling oligonucleotides to phenylalanine (Phe)-based polymers. Unlike prototypical DNA block copolymers, which typically form simple spherical micelles, DNA-b-poly(amino acid) assemble into various low-dimensional structures such as nanofibers, ribbons, and sheets through controllable amino acid interactions. Moreover, DNA-b-poly(amino acid) assemblies can undergo protease-induced fiber-to-sheet shape transformations, where the morphology change is dictated by the type of enzymes and amino acid sequences. The peptide-based self-assembly reported here provides a programmable approach to fabricate dynamic DNA assemblies with diverse and unusual low-dimensional structures. © 2020 American Chemical Society.
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